TY - JOUR AU - Serrano-Lopez, Juana AU - Hegde, Shailaja AU - Kumar, Sachin AU - Serrano, Josefina AU - Fang, Jing AU - Wellendorf, Ashley M AU - Roche, Paul A AU - Rangel, Yamileth AU - Carrington, Leolene J AU - Geiger, Hartmut AU - Grimes, H Leighton AU - Luther, Sanjiv AU - Maillard, Ivan AU - Sanchez-Garcia, Joaquin AU - Starczynowski, Daniel T AU - Cancelas, Jose A PY - 2021 DO - 10.7554/eLife.66190 UR - http://hdl.handle.net/10668/17543 T2 - eLife AB - Innate immune cellular effectors are actively consumed during systemic inflammation, but the systemic traffic and the mechanisms that support their replenishment remain unknown. Here, we demonstrate that acute systemic inflammation induces the... LA - en PB - eLife Sciences Publications KW - Bone marrow KW - Circulation KW - Endotoxemia KW - Human KW - Immunology KW - Inflammation KW - Lymphatics KW - Medicine KW - Mouse KW - Myeloid progenitors KW - Adolescent KW - Adult KW - Aged KW - Aged, 80 and over KW - Animals KW - Bone marrow KW - Cell lineage KW - Cell movement KW - Cells, cultured KW - Child KW - Child, preschool KW - Disease models, animal KW - Female KW - Granulocyte-macrophage progenitor cells KW - Humans KW - Inflammation KW - Inflammation mediators KW - Lymphadenopathy KW - Lymphatic system TI - Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics. TY - research article VL - 10 ER -