RT Journal Article
T1 Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics.
A1 Serrano-Lopez, Juana
A1 Hegde, Shailaja
A1 Kumar, Sachin
A1 Serrano, Josefina
A1 Fang, Jing
A1 Wellendorf, Ashley M
A1 Roche, Paul A
A1 Rangel, Yamileth
A1 Carrington, Leolene J
A1 Geiger, Hartmut
A1 Grimes, H Leighton
A1 Luther, Sanjiv
A1 Maillard, Ivan
A1 Sanchez-Garcia, Joaquin
A1 Starczynowski, Daniel T
A1 Cancelas, Jose A
K1 Bone marrow
K1 Circulation
K1 Endotoxemia
K1 Human
K1 Immunology
K1 Inflammation
K1 Lymphatics
K1 Medicine
K1 Mouse
K1 Myeloid progenitors
AB Innate immune cellular effectors are actively consumed during systemic inflammation, but the systemic traffic and the mechanisms that support their replenishment remain unknown. Here, we demonstrate that acute systemic inflammation induces the emergent activation of a previously unrecognized system of rapid migration of granulocyte-macrophage progenitors and committed macrophage-dendritic progenitors, but not other progenitors or stem cells, from bone marrow (BM) to regional lymphatic capillaries. The progenitor traffic to the systemic lymphatic circulation is mediated by Ccl19/Ccr7 and is NF-κB independent, Traf6/IκB-kinase/SNAP23 activation dependent, and is responsible for the secretion of pre-stored Ccl19 by a subpopulation of CD205+/CD172a+ conventional dendritic cells type 2 and upregulation of BM myeloid progenitor Ccr7 signaling. Mature myeloid Traf6 signaling is anti-inflammatory and necessary for lymph node myeloid cell development. This report unveils the existence and the mechanistic basis of a very early direct traffic of myeloid progenitors from BM to lymphatics during inflammation.
PB eLife Sciences Publications
YR 2021
FD 2021-04-07
LK http://hdl.handle.net/10668/17543
UL http://hdl.handle.net/10668/17543
LA en
NO Serrano-Lopez J, Hegde S, Kumar S, Serrano J, Fang J, Wellendorf AM, et al. Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics. Elife. 2021 Apr 8;10:e66190
DS RISalud
RD Apr 11, 2025