RT Journal Article T1 Effective Tetradentate Compound Complexes against Leishmania spp. that Act on Critical Enzymatic Pathways of These Parasites. A1 Urbanová, Kristína A1 Ramírez-Macías, Inmaculada A1 Martín-Escolano, Rubén A1 Rosales, María José A1 Cussó, Olaf A1 Serrano, Joan A1 Company, Anna A1 Sánchez-Moreno, Manuel A1 Costas, Miquel A1 Ribas, Xavi A1 Marín, Clotilde K1 Leishmania spp. K1 SOD K1 amastigote K1 antileishmania K1 antiproliferative K1 promastigote K1 tetradentate polyaminic compounds K1 ultrastructure AB The spectrum and efficacy of available antileishmanial drugs is limited. In the present work we evaluated in vitro the antiproliferative activity of 11 compounds based on tetradentate polyamines compounds against three Leishmania species (L. braziliensis, L. donovani and L. infantum) and the possible mechanism of action. We identified six compounds (3, 5, 6, 7, 8 and 10) effective against all three Leishmania spp both on extracellular and intracellular forms. These six most active leishmanicidal compounds also prevent the infection of host cells. Nevertheless, only compound 7 is targeted against the Leishmania SOD. Meanwhile, on the glucose metabolism the tested compounds have a species-specific effect on Leishmania spp.: L. braziliensis was affected mainly by 10 and 8, L. donovani by 7, and L. infantum by 5 and 3. Finally, the cellular ultrastructure was mainly damaged by 11 in the three Leishmania spp. studied. These identified antileishmania candidates constitute a good alternative treatment and will be further studied. YR 2018 FD 2018-12-31 LK http://hdl.handle.net/10668/13370 UL http://hdl.handle.net/10668/13370 LA en DS RISalud RD Feb 15, 2025