RT Journal Article T1 Clinical practice guidelines with recommendations for peripartum depression: A European systematic review. A1 Motrico, Emma A1 Moreno-Peral, Patricia A1 Uriko, Kristiina A1 Hancheva, Camellia A1 Brekalo, Maja A1 Ajaz, Erilda A1 Apter, Gisele A1 Bramante, Alessandra A1 Conejo-Cerón, Sonia A1 Christoforou, Andri A1 Dikmen-Yildiz, Pelin A1 Evagorou, Olympia A1 Fonseca, Ana A1 Lupattelli, Angela A1 Radoš, Sandra Nakić A1 Al Maach, Nadia A1 Rodriguez-Muñoz, María F A1 Žutić, Maja A1 Lambregtse-van den Berg, Mijke P K1 clinical practice guidelines K1 depression K1 perinatal K1 peripartum K1 systematic review AB This study aims to systematically review all Clinical Practice Guidelines (CPGs) with recommendations for peripartum depression in European countries. A systematic review according to the PRISMA statement was conducted. CPGs focussing on peripartum depression or with at least one specific recommendation for peripartum depression from European countries were selected. Searching was conducted in electronic databases (MEDLINE and PsycINFO), and by contacting professional societies and international experts until November 24th, 2021. Characteristics of the included CPGs and their recommendations were extracted. A methodological quality assessment was conducted using the AGREE-II tool. A total of 239 records were identified after duplicate removal. Of these, 54 were examined for full-text inspection. The final selection yielded 14 CPGs from 11 European countries in 10 languages. Of them, 11 provided recommendations on pharmacological treatments, 10 on psychological treatment (e.g., cognitive-behavioural therapy), 10 on screening, 8 on diagnosis, 6 on other treatments (e.g., physical exercise), 5 on prevention, and 5 other recommendations (e.g., provide information). Regarding the overall methodological quality, only five (35.7%) guidelines were rated as of adequate quality, reaching a score ≥ 70% in the overall assessment of the AGREE-II instrument. Of the six AGREE-II domains, applicability scored the lowest and clarity of presentation scored the highest. The absence of CPGs in most European countries, the discrepancy in recommendations and the low methodological quality of the guidelines may lead to disparities and inequalities in peripartum depression management in Europe. The COST Action Riseup-PPD highlights key considerations for future guideline developers. YR 2022 FD 2022-08-24 LK http://hdl.handle.net/10668/19884 UL http://hdl.handle.net/10668/19884 LA en DS RISalud RD Apr 9, 2025