RT Journal Article
T1 New developments in RiPP discovery, enzymology and engineering.
A1 Montalbán-López, Manuel
A1 Scott, Thomas A
A1 Ramesh, Sangeetha
A1 Rahman, Imran R
A1 van Heel, Auke J
A1 Viel, Jakob H
A1 Bandarian, Vahe
A1 Dittmann, Elke
A1 Genilloud, Olga
A1 Goto, Yuki
A1 Grande Burgos, María José
A1 Hill, Colin
A1 Kim, Seokhee
A1 Koehnke, Jesko
A1 Latham, John A
A1 Link, A James
A1 Martínez, Beatriz
A1 Nair, Satish K
A1 Nicolet, Yvain
A1 Rebuffat, Sylvie
A1 Sahl, Hans-Georg
A1 Sareen, Dipti
A1 Schmidt, Eric W
A1 Schmitt, Lutz
A1 Severinov, Konstantin
A1 Süssmuth, Roderich D
A1 Truman, Andrew W
A1 Wang, Huan
A1 Weng, Jing-Ke
A1 van Wezel, Gilles P
A1 Zhang, Qi
A1 Zhong, Jin
A1 Piel, Jörn
A1 Mitchell, Douglas A
A1 Kuipers, Oscar P
A1 van der Donk, Wilfred A
AB Covering: up to June 2020Ribosomally-synthesized and post-translationally modified peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 described the emerging commonalities in the biosynthesis of RiPPs and the opportunities they offered for bioengineering and genome mining. Since then, the field has seen tremendous advances in understanding of the mechanisms by which nature assembles these compounds, in engineering their biosynthetic machinery for a wide range of applications, and in the discovery of entirely new RiPP families using bioinformatic tools developed specifically for this compound class. The First International Conference on RiPPs was held in 2019, and the meeting participants assembled the current review describing new developments since 2013. The review discusses the new classes of RiPPs that have been discovered, the advances in our understanding of the installation of both primary and secondary post-translational modifications, and the mechanisms by which the enzymes recognize the leader peptides in their substrates. In addition, genome mining tools used for RiPP discovery are discussed as well as various strategies for RiPP engineering. An outlook section presents directions for future research.
YR 2020
FD 2020-09-16
LK http://hdl.handle.net/10668/16260
UL http://hdl.handle.net/10668/16260
LA en
DS RISalud
RD Apr 9, 2025