RT Journal Article
T1 Subclinical Atherosclerosis Measure by Carotid Ultrasound and Inflammatory Activity in Patients with Rheumatoid Arthritis and Spondylarthritis.
A1 Rojas-Gimenez, Marta
A1 Lopez-Medina, Clementina
A1 Ladehesa-Pineda, Maria Lourdes
A1 Puche-Larrubia, Maria Angeles
A1 Gomez-Garcia, Ignacio
A1 Calvo-Gutierrez, Jerusalem
A1 Segui-Azpilcueta, Pedro
A1 Abalos-Aguilera, Maria Del Carmen
A1 Ruiz-Vilchez, Desiree
A1 Escudero-Contreras, Alejandro
A1 Collantes-Estevez, Eduardo
K1 Cardiovascular risk
K1 Inflammatory activity
K1 Rheumatoid arthritis
K1 Spondyloarthritis
K1 Subclinical atherosclerosis
AB To compare the effect of inflammation on subclinical atherosclerosis using carotid ultrasound in patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA). Cross-sectional study including 347 participants (148 RA, 159 SpA, and 40 controls). We measured the carotid intima media thickness (cIMT) and detection of atheromatous plaques using carotid ultrasound. We recorded disease activity (DAS28-CRP/ASDAS-CRP) and traditional cardiovascular risk factors. We performed descriptive, bivariate, and linear multivariate analyses (dependent variable: cIMT) to evaluate the influence of diagnosis on cIMT in all patients. Two additional multivariate analyses were performed by stratifying patients according to their inflammatory activity. cIMT correlated with the mean CRP during the previous 5 years in RA, but not with CRP at the cut-off date. We did not find such differences in patients with SpA. The first multivariate model revealed that increased cIMT was more common in patients with RA than in those with SpA (β coefficient, 0.045; 95% confidence interval (95% CI), 0.0002-0.09; p = 0.048) after adjusting for age, sex, disease course, and differential cardiovascular risk factors (arterial hypertension, smoking, statins, and corticosteroids). The second model revealed no differences in cIMT between the 2 groups of patients classified as remission-low activity (β coefficient, 0.020; 95% CI, -0.03 to 0.080; p = 0.500). However, when only patients with moderate-high disease activity were analysed, the cIMT was 0.112 mm greater in those with RA (95% CI, 0.013-0.212; p = 0.026) than in those with SpA after adjusting for the same variables. Subclinical atherosclerosis measured by carotid ultrasound in patients with RA and SpA is comparable when the disease is well controlled. However, when patients have moderate-high disease activity, cIMT is greater in patients with RA than in those with SpA after adjusting for age, sex, disease course, and cardiovascular risk factors. Our results point to greater involvement of disease activity in subclinical atherosclerosis in patients with RA than in those with SpA.
PB MDPI
SN 2077-0383
YR 2022
FD 2022-01-24
LK http://hdl.handle.net/10668/21237
UL http://hdl.handle.net/10668/21237
LA en
NO Rojas-Giménez M, López-Medina C, Ladehesa-Pineda ML, Puche-Larrubia MÁ, Gómez-García I, Calvo-Gutiérrez J, et al. Subclinical Atherosclerosis Measure by Carotid Ultrasound and Inflammatory Activity in Patients with Rheumatoid Arthritis and Spondylarthritis. J Clin Med. 2022 Jan 27;11(3):662
DS RISalud
RD Apr 14, 2025