RT Journal Article
T1 Synthesis and Characterization of Specific Reverse Transcriptase Inhibitors for Mammalian LINE-1 Retrotransposons.
A1 Banuelos-Sanchez, Guillermo
A1 Sanchez, Laura
A1 Benitez-Guijarro, Maria
A1 Sanchez-Carnerero, Valentin
A1 Salvador-Palomeque, Carmen
A1 Tristan-Ramos, Pablo
A1 Benkaddour-Boumzaouad, Meriem
A1 Morell, Santiago
A1 Garcia-Puche, Jose L
A1 Heras, Sara R
A1 Franco-Montalban, Francisco
A1 Tamayo, Juan A
A1 Garcia-Perez, Jose L
K1 LINE-1
K1 LTR-retrotransposon
K1 brain genomic mosaicism
K1 cancer
K1 nucleoside analog
K1 retrotransposition
K1 reverse transcriptase
AB Retrotransposons are a type of transposable element (TE) that have amplified to astonishing numbers in mammalian genomes, comprising more than a third of the human and mouse genomes. Long interspersed element class 1 (LINE-1 or L1) retrotransposons are abundant and currently active retroelements in the human and mouse genomes. Similarly, long terminal repeat (LTR)-containing retrotransposons are abundant in both genomes, although only active in mice. LTR- and LINE-1-retroelements use different mechanisms for retrotransposition, although both involve the reverse transcription of an intermediate retroelement-derived RNA. Retrotransposon activity continues to effect the germline and somatic genomes, generating interindividual variability over evolution and potentially influencing cancer and brain physiology, respectively. However, relatively little is known about the functional consequences of retrotransposition. In this study, we have synthesized and characterized reverse transcriptase inhibitors specific for mammalian LINE-1 retrotransposons, which might help deciphering the functional impact of retrotransposition in vivo.
YR 2019
FD 2019-05-30
LK http://hdl.handle.net/10668/14059
UL http://hdl.handle.net/10668/14059
LA en
DS RISalud
RD Apr 7, 2025