RT Journal Article
T1 Hallmarks of Cancer Applied to Oral and Oropharyngeal Carcinogenesis: A Scoping Review of the Evidence Gaps Found in Published Systematic Reviews.
A1 Gonzalez-Moles, Miguel Angel
A1 Warnakulasuriya, Saman
A1 Lopez-Ansio, Maria
A1 Ramos-Garcia, Pablo
K1 biomarkers
K1 hallmarks of cancer
K1 meta-analysis
K1 oral cancer
K1 oral potentially malignant disorders
K1 oropharyngeal cancer
K1 scoping review
K1 systematic review
AB In 2000 and 2011, Hanahan and Weinberg published two papers in which they defined the characteristics that cells must fulfil in order to be considered neoplastic cells in all types of tumours that affect humans, which the authors called "hallmarks of cancer". These papers have represented a milestone in our understanding of the biology of many types of cancers and have made it possible to reach high levels of scientific evidence in relation to the prognostic impact that these hallmarks have on different tumour types. However, to date, there is no study that globally analyses evidence-based knowledge on the importance of these hallmarks in oral and oropharyngeal squamous cell carcinomas. For this reason, we set out to conduct this scoping review of systematic reviews with the aim of detecting evidence gaps in relation to the relevance of the cancer hallmarks proposed by Hanahan and Weinberg in oral and oropharyngeal cancer, and oral potentially malignant disorders, and to point out future lines of research in this field.
PB MDPI AG
SN 2072-6694
YR 2022
FD 2022-08-04
LK http://hdl.handle.net/10668/20911
UL http://hdl.handle.net/10668/20911
LA en
NO González-Moles MÁ, Warnakulasuriya S, López-Ansio M, Ramos-García P. Hallmarks of Cancer Applied to Oral and Oropharyngeal Carcinogenesis: A Scoping Review of the Evidence Gaps Found in Published Systematic Reviews. Cancers (Basel). 2022 Aug 8;14(15):3834.
DS RISalud
RD Apr 19, 2025