RT Journal Article
T1 Role of Nitric Oxide in Gene Expression Regulation during Cancer: Epigenetic Modifications and Non-Coding RNAs
A1 de la Cruz-Ojeda, Patricia
A1 Flores-Campos, Rocío
A1 Dios-Barbeito, Sandra
A1 Navarro-Villarán, Elena
A1 Muntané, Jordi
K1 Hepatocarcinoma
K1 miRNA
K1 Nitric oxide synthase
K1 lncRNA
K1 Tumor-associated macrophages
K1 Cancer associated fibroblasts
K1 Cancer stem cells
K1 MicroARNs
K1 Óxido nítrico sintasa
K1 ARN largo no codificante
K1 Macrófagos asociados a tumores
K1 Fibroblastos asociados al cáncer
K1 Células madre neoplásicas
AB Nitric oxide (NO) has been identified and described as a dual mediator in cancer according to dose-, time- and compartment-dependent NO generation. The present review addresses the different epigenetic mechanisms, such as histone modifications and non-coding RNAs (ncRNAs), miRNA and lncRNA, which regulate directly or indirectly nitric oxide synthase (NOS) expression and NO production, impacting all hallmarks of the oncogenic process. Among lncRNA, HEIH and UCA1 develop their oncogenic functions by inhibiting their target miRNAs and consequently reversing the inhibition of NOS and promoting tumor proliferation. The connection between miRNAs and NO is also involved in two important features in cancer, such as the tumor microenvironment that includes key cellular components such as tumor-associated macrophages (TAMs), cancer associated fibroblasts (CAFs) and cancer stem cells (CSCs).
PB MDPI
YR 2021
FD 2021-06-10
LK http://hdl.handle.net/10668/3656
UL http://hdl.handle.net/10668/3656
LA en
NO de la Cruz-Ojeda P, Flores-Campos R, Dios-Barbeito S, Navarro-Villarán E, Muntané J. Role of Nitric Oxide in Gene Expression Regulation during Cancer: Epigenetic Modifications and Non-Coding RNAs. Int J Mol Sci. 2021 Jun 10;22(12):6264
DS RISalud
RD Apr 8, 2025