RT Journal Article
T1 Intake of Total Polyphenols and Some Classes of Polyphenols Is Inversely Associated with Diabetes in Elderly People at High Cardiovascular Disease Risk
A1 Tresserra-Rimbau, Anna
A1 Guasch-Ferre, Marta
A1 Salas-Salvado, Jordi
A1 Toledo, Estefania
A1 Corella, Dolores
A1 Castaner, Olga
A1 Guo, Xiaohui
A1 Gomez-Gracia, Enrique
A1 Lapetra, Jose
A1 Aros, Fernando
A1 Fiol, Miquel
A1 Ros, Emili
A1 Serra-Majem, Lluis
A1 Pinto, Xavier
A1 Fito, Montserrat
A1 Babio, Nancy
A1 Martinez-Gonzalez, Miguel A.
A1 Sorli, Jose V.
A1 Carmen Lopez-Sabater, M.
A1 Estruch, Ramon
A1 Lamuela-Raventos, Rosa M.
A1 PREDIMED Study Investigators, 
K1 chronic disease
K1 cox regression
K1 epidemiology
K1 glucose
K1 observational study
K1 Total-energy intake
K1 Dietary patterns
K1 Postmenopausal women
K1 European populations
K1 Insulin sensitivity
K1 Glucose-metabolism
K1 Mediterranean diet
K1 Randomized-trial
K1 Food sources
K1 2 cohorts
AB Background: Higher consumption of some polyphenols has been associated with a reduced risk of diabetes. However, no studies have evaluated the relation between all polyphenol subclasses and the incidence of diabetes.Objective: We aimed to prospectively examine the associations between the intake of total polyphenols and different groups of polyphenols (flavonoids, phenolic acids, stilbenes, lignans, and others) on the risk of incident diabetes in the PREDIMED (Prevencion con Dieta Mediterranea) trial.Methods: This was an observational cohort analysis of the nondiabetic participants in the PREDIMED trial. This study was a multicenter, controlled, randomized, parallel-group feeding trial to assess the effects of either a Mediterranean diet that was supplemented with extra-virgin olive oil or nuts or advice to adhere to a low-fat control diet on cardiovascular outcomes in elderly men and women at high cardiovascular disease risk. From the 7447 randomly assigned participants, 3430 were selected because they were free of diabetes at baseline and filled out the food-frequency questionnaires (FFQs). Polyphenol intake was calculated by matching food consumption data from repeated FFQs with the Phenol-Explorer database on the polyphenol content of each reported food. HRs and 95% CIs for diabetes according to tertiles of polyphenol intake were estimated with the use of time-dependent Cox proportional hazards models.Results: Over a mean of 5.51 y of follow-up (18,900 person-years), there were 314 new cases of diabetes. After multivariable adjustment, we observed a 28% reduction in new-onset diabetes in the highest compared with the lowest tertile of total polyphenol intake (HR: 0.72; 95% CI: 0.52, 0.99; P-trend = 0.05). The intake of subclasses of polyphenols also was inversely associated with diabetes risk, including for total flavonoids (HR: 0.67; 95% CI: 0.48, 0.93; P-trend = 0.02), stilbenes (HR: 0.57; 95% CI: 0.38, 0.84; P-trend = 0.003), dihydroflavonols (HR: 0.59; 95% CI: 0.40, 0.88; P-trend = 0.003), and flavanones (HR: 0.69; 95% CI: 0.49, 0.97; P-trend = 0.03).Conclusions: A high intake of total polyphenols, total flavonoids (specifically flavanones and dihydroflavonols), and stilbenes is associated with a reduced risk of diabetes in elderly persons at high risk of cardiovascular disease. This trial was registered at http://www.controlled-trials.com as ISRCTN35739639.
PB Oxford univ press
SN 0022-3166
YR 2016
FD 2016-04-01
LK http://hdl.handle.net/10668/19343
UL http://hdl.handle.net/10668/19343
LA en
DS RISalud
RD Apr 9, 2025