RT Journal Article
T1 The Escape of Cancer from T Cell-Mediated Immune Surveillance: HLA Class I Loss and Tumor Tissue Architecture
A1 Garrido, Federico
A1 Perea, Francisco
A1 Bernal, Mónica
A1 Sánchez-Palencia, Abel
A1 Aptsiauri, Natalia
A1 Ruiz-Cabello, Francisco
K1 HLA class I loss
K1 Tumor infiltrating lymphocytes (TILs)
K1 Tumor immune escape
K1 Humanos
K1 Inmunoterapia
K1 Activación de linfocitos
K1 Macrófagos
K1 Mutación
K1 Neoplasia
K1 Linfocitos t citotóxicos
K1 Escape del Tumor
K1 Microambiente tumoral
AB Tumor immune escape is associated with the loss of tumor HLA class I (HLA-I) expression commonly found in malignant cells. Accumulating evidence suggests that the efficacy of immunotherapy depends on the expression levels of HLA class I molecules on tumors cells. It also depends on the molecular mechanism underlying the loss of HLA expression, which could be reversible/"soft" or irreversible/"hard" due to genetic alterations in HLA, β2-microglobulin or IFN genes. Immune selection of HLA-I negative tumor cells harboring structural/irreversible alterations has been demonstrated after immunotherapy in cancer patients and in experimental cancer models. Here, we summarize recent findings indicating that tumor HLA-I loss also correlates with a reduced intra-tumor T cell infiltration and with a specific reorganization of tumor tissue. T cell immune selection of HLA-I negative tumors results in a clear separation between the stroma and the tumor parenchyma with leucocytes, macrophages and other mononuclear cells restrained outside the tumor mass. Better understanding of the structural and functional changes taking place in the tumor microenvironment may help to overcome cancer immune escape and improve the efficacy of different immunotherapeutic strategies. We also underline the urgent need for designing strategies to enhance tumor HLA class I expression that could improve tumor rejection by cytotoxic T-lymphocytes (CTL).
PB MDPI
YR 2017
FD 2017-02-27
LK http://hdl.handle.net/10668/2691
UL http://hdl.handle.net/10668/2691
LA en
NO Garrido F,  Perea F, Bernal M, Sánchez-Palencia A, Aptsiauri N, Ruiz-Cabello F. The Escape of Cancer from T Cell-Mediated Immune Surveillance: HLA Class I Loss and Tumor Tissue Architecture. Vaccines (Basel). 2017;5(1). pii: E7
NO (This article belongs to the Special Issue Mechanisms of Tumor Escape from Host Immunity)
DS RISalud
RD Apr 4, 2025