RT Journal Article
T1 Safety and efficacy of the mesenchymal stem cell in feline eosinophilic keratitis treatment.
A1 Villatoro, Antonio J
A1 Claros, Silvia
A1 Fernández, Viviana
A1 Alcoholado, Cristina
A1 Fariñas, Fernando
A1 Moreno, Antonio
A1 Becerra, José
A1 Andrades, José A
K1 Adipose mesenchymal stem cell
K1 Allogeneic cell therapy
K1 Cat
K1 Feline eosinophilic keratitis
K1 Feline herpes virus
K1 Lacrimal gland
AB Feline eosinophilic keratitis (FEK) is a chronic keratopathy caused by a suspected immune mediated response to an unknown antigenic stimulus. The purpose of this study was to investigate the safety and therapeutic effects of allogeneic feline adipose-derived mesenchymal stromal cells (fAd-MSCs) implanted subconjunctival around the ocular surface lesion in five cats with FEK refractory to current available treatments. FEK was diagnosed by clinical appearance and evidence of eosinophil and/or mast cells in corneal cytology. Each animal was treated with two applications of 2 × 106 million of fAd-MSCs 2 months apart. Ocular surface integrity was assessed before treatment and at 1, 3, 6 and 11 months after treatment. Clinical signs showed a significant change during the follow-up with resolution of the corneal and conjunctiva lesions and there were no signs of regression or worsening. Implanted cells were well-tolerated and effective reducing clinical signs of FEK with a sustained effect during the study period. None of the animals showed systemic or local complications during the study. To our knowledge, this is the first time in literature that local implantation of allogeneic fAd-MSCs has been found as an effective therapeutic alternative to treat cats with FEK.
YR 2018
FD 2018-03-27
LK http://hdl.handle.net/10668/12281
UL http://hdl.handle.net/10668/12281
LA en
DS RISalud
RD Jul 30, 2025