RT Journal Article
T1 Preventive effects of Brassicaceae family for colon cancer prevention: A focus on in vitro studies.
A1 Peña, Mercedes
A1 Guzman, Ana
A1 Martinez, Rosario
A1 Mesas, Cristina
A1 Prados, Jose
A1 Porres, Jesus M
A1 Melguizo, Consolacion
K1 Antitumor activity
K1 Bioactive compounds
K1 Brassicaceae family
K1 Colon cancer
K1 in vitro assay
AB The emergence of adverse effects and resistance to colorectal cancer (CRC) current therapies calls for the development of new strategies aimed at both preventing and treating. In this context, functional extracts from Brassicaceae family contains abundant bioactive compounds directly related to a positive effect on human health including cancer. The main objective of this systematic review is to compile all recent studies that analyzed the in vitro antiproliferative activity of functional extracts or isolated molecules from the Brassicaceae family against CRC. A total of 711 articles published between January 2011 and May 2021 were identified. Of them, 68 met our inclusion criteria. Different standardized protocols using variable parts of plants of the Brassicaceae family resulted in diverse bioactive extracts and/or compounds. Most of them were related to isothiocyanates, which showed significant antitumor activity against CRC. These in vitro studies provide an excellent guide to direct research on the applications of plants of the Brassicaceae family to the prevention of this type of tumor. The extracts and molecules with demonstrated activity against CRC should be tested in vivo and in clinical trials to determine their usefulness in the prevention of this cancer to reduce its global incidence.
PB Elsevier Masson
YR 2022
FD 2022-05-15
LK http://hdl.handle.net/10668/22044
UL http://hdl.handle.net/10668/22044
LA en
NO Peña M, Guzmán A, Martínez R, Mesas C, Prados J, Porres JM, et al. Preventive effects of Brassicaceae family for colon cancer prevention: A focus on in vitro studies. Biomed Pharmacother. 2022 Jul;151:113145
NO This research was funded by the Ministerio de Ciencia, Innovación y Universidades through the project RTC2019-006870-1 (FEDER program) and Junta de Andalucía through project P18-TP-1420 (FEDER program), both with the collaboration between Granada University and CELLBITEC S.L. MP acknowledges the FPU2019 (Ref. FPU19/06170) grant from the Ministerio de Universidades (Spain) and AG acknowledges the Industrial PhD Grants 2018 (Ref. DIN2018-009995B04847216) from the Ministerio de Ciencia, Innovación y Universidades (Spain). In addition, this work was supported by funds from research groups AGR145 and CTS-107 (Andalusian Government).
DS RISalud
RD Apr 6, 2025