RT Journal Article
T1 Biocompatibility and Cellular Behavior of TiNbTa Alloy with Adapted Rigidity for the Replacement of Bone Tissue
A1 Giner, Merce
A1 Chicardi, Ernesto
A1 Costa, Alzenira de Fatima
A1 Santana, Laura
A1 Vazquez-Gamez, Maria Angeles
A1 Garcia-Garrido, Cristina
A1 Colmenero, Miguel Angel
A1 Olmo-Montes, Francisco Jesus
A1 Torres, Yadir
A1 Montoya-Garcia, Maria Jose
K1 prosthetic material
K1 TiNbTa
K1 osteoblastic cells
K1 cellular adhesion
K1 porous titanium
K1 mechanical behavior
AB In this work, the mechanical and bio-functional behavior of a TiNbTa alloy is evaluated as a potential prosthetic biomaterial used for cortical bone replacement. The results are compared with the reference Ti c.p. used as biomaterials for bone-replacement implants. The estimated mechanical behavior for TiNbTa foams was also compared with the experimental Ti c.p. foams fabricated by the authors in previous studies. A TiNbTa alloy with a 20-30% porosity could be a candidate for the replacement of cortical bone, while levels of 80% would allow the manufacture of implants for the replacement of trabecular bone tissue. Regarding biocompatibility, in vitro TiNbTa, cellular responses (osteoblast adhesion and proliferation) were compared with cell growth in Ti c.p. samples. Cell adhesion (presence of filopodia) and propagation were promoted. The TiNbTa samples had a bioactive response similar to that of Ti c.p. However, TiNbTa samples show a better balance of bio-functional behavior (promoting osseointegration) and biomechanical behavior (solving the stress-shielding phenomenon and guaranteeing mechanical resistance).
PB Mdpi
YR 2021
FD 2021-01-01
LK http://hdl.handle.net/10668/19302
UL http://hdl.handle.net/10668/19302
LA en
DS RISalud
RD Apr 6, 2025