RT Journal Article
T1 Associated factors to serious infections in a large cohort of juvenile-onset systemic lupus erythematosus from Lupus Registry (RELESSER).
A1 Torrente-Segarra, Vicenç
A1 Salman-Monte, Tarek C
A1 Rúa-Figueroa, Íñigo
A1 Del Campo, Víctor
A1 López-Longo, Francisco Javier
A1 Galindo-Izquierdo, María
A1 Calvo-Alén, Jaime
A1 Olivé-Marqués, Alejandro
A1 Mouriño-Rodríguez, Coral
A1 Horcada, Loreto
A1 Bohórquez, Cristina
A1 Montilla, Carlos
A1 Salgado, Eva
A1 Díez-Álvarez, Elvira
A1 Blanco, Ricardo
A1 Andreu, José Luis
A1 Fernández-Berrizbeitia, Olaia
A1 Expósito, Lorena
A1 Gantes, Marian
A1 Hernández-Cruz, Blanca
A1 Pecondón-Español, Ángela
A1 Lozano-Rivas, Nuria
A1 Bonilla, Gema
A1 Lois Iglesias, Ana
A1 Rubio-Muñoz, Paula
A1 Ovalles, Juan
A1 Tomero, Eva
A1 Boteanu, Alina
A1 Narvaez, Javier
A1 Freire, Mercedes
A1 Vela, Paloma
A1 Quevedo-Vila, Víctor
A1 Juan Mas, Antonio
A1 Muñoz-Fernández, Santiago
A1 Raya, Enrique
A1 Moreno, Mireia
A1 Velloso-Feijoo, M L
A1 Soler, Gregorio
A1 Vázquez-Rodríguez, Tomás Ramón
A1 Pego-Reigosa, José M
A1 RELESSER Study Group of the Spanish Society of Rheumatology (SER) and the Study Group of Systemic Autoimmune Diseases of the SER (EAS-SER), 
K1 Juvenile-onset Systemic Lupus Erythematosus
K1 RELESSER
K1 Serious Infections
AB To assess the incidence of serious infection (SI) and associated factors in a large juvenile-onset systemic lupus erythematosus (jSLE) retrospective cohort. All patients in the Spanish Rheumatology Society Lupus Registry (RELESSER) who meet ≥4 ACR-97 SLE criteria and disease onset  A total of 353 jSLE patients were included: 88.7% female, 14.3 years (± 2.9) of age at diagnosis, 16.0 years (± 9.3) of disease duration and 31.5 years (±10.5) at end of follow-up. A total of 104 (29.5%) patients suffered 205 SI (1, 55.8%; 2-5, 38.4%; and ≥6, 5.8%). Incidence rate was 3.7 (95%CI: 3.2-4.2) SI per 100 patient years. Respiratory location and bacterial infections were the most frequent. Higher number of SLE classification criteria, SLICC/ACR DI score and immunosuppressants use were associated to the presence of SI. Associated factors to shorter time to first infection were higher number of SLE criteria, splenectomy and immunosuppressants use. The risk of SI in jSLE patients is significant and higher than aSLE. It is associated to higher number of SLE criteria, damage accrual, some immunosuppressants and splenectomy.
YR 2020
FD 2020-05-30
LK http://hdl.handle.net/10668/15694
UL http://hdl.handle.net/10668/15694
LA en
DS RISalud
RD Apr 5, 2025