RT Journal Article
T1 Erythema Increase Predicts Psoriasis Improvement after Phototherapy.
A1 Montero-Vilchez, Trinidad
A1 Martinez-Lopez, Antonio
A1 Sierra-Sanchez, Alvaro
A1 Soler-Gongora, Miguel
A1 Jimenez-Mejias, Eladio
A1 Molina-Leyva, Alejandro
A1 Buendia-Eisman, Agustin
A1 Arias-Santiago, Salvador
K1 phototherapy
K1 psoriasis
K1 skin barrier
K1 skin homeostasis
K1 skin physiology
AB Psoriasis is a major global health problem. There is a need to develop techniques to help physicians select the most appropriate cost-effective therapy for each patient. The main objectives of this study are (1) to evaluate changes in epidermal barrier function and skin homeostasis after phototherapy and (2) to explore potentially predictive values in epidermal barrier function and skin homeostasis to assess clinical improvement after fifteen sessions of phototherapy. A total of 76 subjects, 38 patients with plaque-type psoriasis and 38 gender- and age-matched healthy volunteers, were included in the study. Erythema, transepidermal water loss (TEWL), temperature, stratum corneum hydration (SCH), pH, sebum, and antioxidant capacity were measured before and after the first and fifteenth phototherapy session. Erythema (401.09 vs. 291.12 vs. 284.52 AU, p
SN 2077-0383
YR 2021
FD 2021-08-30
LK https://hdl.handle.net/10668/28176
UL https://hdl.handle.net/10668/28176
LA en
DS RISalud
RD Apr 6, 2025