TY - JOUR AU - Miró-Canturri, Andrea AU - Ayerbe-Algaba, Rafael AU - Del Toro, Raquel AU - Mejías, Manuel Enrique-Jiménez AU - Pachón, Jerónimo AU - Smani, Younes PY - 2021 DO - 10.3390/ph14060507 UR - http://hdl.handle.net/10668/4335 T2 - Pharmaceuticals AB - The development of new strategic therapies for multidrug-resistant bacteria, like the use of non-antimicrobial approaches and/or drugs repurposed to be used as monotherapies or in combination with clinically relevant antibiotics, has become urgent. A... LA - en PB - MDPI KW - Repurposing drug KW - Tamoxifen KW - Bacteria KW - Infection KW - Animal model KW - Immune system KW - Reposicionamiento de medicamentos KW - Tamoxifeno KW - Bacterias KW - Infecciones KW - modelos animales KW - Sistema inmunológico KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice KW - Medical Subject Headings::Organisms::Eukaryota::Animals KW - Medical Subject Headings::Organisms::Bacteria::Gram-Negative Bacteria::Gram-Negative Aerobic Bacteria::Gram-Negative Aerobic Rods and Cocci::Moraxellaceae::Acinetobacter::Acinetobacter baumannii KW - Medical Subject Headings::Organisms::Bacteria::Gram-Negative Bacteria::Gram-Negative Aerobic Bacteria::Gram-Negative Aerobic Rods and Cocci::Pseudomonadaceae::Pseudomonas::Pseudomonas aeruginosa KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Interleukins::Interleukin-18 KW - Medical Subject Headings::Organisms::Bacteria::Gram-Negative Bacteria::Gram-Negative Facultatively Anaerobic Rods::Enterobacteriaceae::Escherichia::Escherichia coli KW - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Serine-Threonine Kinases::Mitogen-Activated Protein... KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Microbiological Techniques::Bacteriological Techniques::Bacterial Load KW - Medical Subject Headings::Anatomy::Hemic and Immune Systems::Immune System::Bone Marrow KW - Medical Subject Headings::Anatomy::Hemic and Immune Systems::Immune System::Phagocytes::Neutrophils KW - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Anti-Bacterial Agents TI - Potential Tamoxifen Repurposing to Combat Infections by Multidrug-Resistant Gram-Negative Bacilli TY - research article ER -