RT Journal Article
T1 Pathogenic Pathways and Therapeutic Approaches Targeting Inflammation in Diabetic Nephropathy
A1 Rayego-Mateos, Sandra
A1 Morgado-Pascual, José Luis
A1 Opazo-Ríos, Lucas
A1 Guerrero-Hue, Melania
A1 García-Caballero, Cristina
A1 Vázquez-Carballo, Cristina
A1 Mas, Sebastián
A1 Sanz, Ana Belén
A1 Herencia, Carmen
A1 Mezzano, Sergio
A1 Gómez-Guerrero, Carmen
A1 Moreno, Juan Antonio
A1 Egido, Jesús
K1 Inflammation
K1 Type 2 diabetes
K1 Diabetic nephropathy
K1 Chronic kidney disease
K1 Drugs
K1 Therapy
K1 Inflamación
K1 Diabetes mellitus tipo 2
K1 Nefropatías diabéticas
K1 Insuficiencia renal crónica
K1 Preparaciones farmacéuticas
K1 Terapéutica
AB Diabetic nephropathy (DN) is associated with an increased morbidity and mortality, resulting in elevated cost for public health systems. DN is the main cause of chronic kidney disease (CKD) and its incidence increases the number of patients that develop the end-stage renal disease (ESRD). There are growing epidemiological and preclinical evidence about the close relationship between inflammatory response and the occurrence and progression of DN. Several anti-inflammatory strategies targeting specific inflammatory mediators (cell adhesion molecules, chemokines and cytokines) and intracellular signaling pathways have shown beneficial effects in experimental models of DN, decreasing proteinuria and renal lesions. A number of inflammatory molecules have been shown useful to identify diabetic patients at high risk of developing renal complications. In this review, we focus on the key role of inflammation in the genesis and progression of DN, with a special interest in effector molecules and activated intracellular pathways leading to renal damage, as well as a comprehensive update of new therapeutic strategies targeting inflammation to prevent and/or retard renal injury.
PB MDPI
YR 2020
FD 2020-05-27
LK http://hdl.handle.net/10668/3594
UL http://hdl.handle.net/10668/3594
LA en
NO Rayego-Mateos S, Morgado-Pascual JL, Opazo-Ríos L, Guerrero-Hue M, García-Caballero C, Vázquez-Carballo C, et al. Pathogenic Pathways and Therapeutic Approaches Targeting Inflammation in Diabetic Nephropathy. Int J Mol Sci. 2020 May 27;21(11):3798
DS RISalud
RD Apr 20, 2025