RT Journal Article
T1 Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium.
A1 Farzan, Niloufar
A1 Vijverberg, Susanne J
A1 Andiappan, Anand K
A1 Arianto, Lambang
A1 Berce, Vojko
A1 Blanca-López, Natalia
A1 Bisgaard, Hans
A1 Bønnelykke, Klaus
A1 Burchard, Esteban G
A1 Campo, Paloma
A1 Canino, Glorisa
A1 Carleton, Bruce
A1 Celedón, Juan C
A1 Chew, Fook Tim
A1 Chiang, Wen Chin
A1 Cloutier, Michelle M
A1 Daley, Denis
A1 Den Dekker, Herman T
A1 Dijk, F Nicole
A1 Duijts, Liesbeth
A1 Flores, Carlos
A1 Forno, Erick
A1 Hawcutt, Daniel B
A1 Hernandez-Pacheco, Natalia
A1 de Jongste, Johan C
A1 Kabesch, Michael
A1 Koppelman, Gerard H
A1 Manolopoulos, Vangelis G
A1 Melén, Erik
A1 Mukhopadhyay, Somnath
A1 Nilsson, Sara
A1 Palmer, Colin N
A1 Pino-Yanes, Maria
A1 Pirmohamed, Munir
A1 Potočnik, Uros
A1 Raaijmakers, Jan A
A1 Repnik, Katja
A1 Schieck, Maximilian
A1 Sio, Yang Yie
A1 Smyth, Rosalind L
A1 Szalai, Csaba
A1 Tantisira, Kelan G
A1 Turner, Steve
A1 van der Schee, Marc P
A1 Verhamme, Katia M
A1 Maitland-van der Zee, Anke H
K1 asthma
K1 children
K1 consortium
K1 genetics
K1 pharmacogenomics
K1 treatment
AB International collaboration is needed to enable large-scale pharmacogenomics studies in childhood asthma. Here, we describe the design of the Pharmacogenomics in Childhood Asthma (PiCA) consortium. Investigators of each study participating in PiCA provided data on the study characteristics by answering an online questionnaire. A total of 21 studies, including 14,227 children/young persons (58% male), from 12 different countries are currently enrolled in the PiCA consortium. Fifty six percent of the patients are Caucasians. In total, 7619 were inhaled corticosteroid users. Among patients from 13 studies with available data on asthma exacerbations, a third reported exacerbations despite inhaled corticosteroid use. In the future pharmacogenomics studies within the consortium, the pharmacogenomics analyses will be performed separately in each center and the results will be meta-analyzed. PiCA is a valuable platform to perform pharmacogenetics studies within a multiethnic pediatric asthma population.
YR 2017
FD 2017-06-22
LK http://hdl.handle.net/10668/11332
UL http://hdl.handle.net/10668/11332
LA en
DS RISalud
RD Apr 8, 2025