RT Generic
T1 Obesity and Asthma: A Missing Link
A1 Amelia Gomez-Llorente, Ma
A1 Romero, Raquel
A1 Chueca, Natalia
A1 Martinez-Canavate, Ana
A1 Gomez-Llorente, Carolina
K1 obesity
K1 asthma
K1 gastrointestinal microbiome
K1 adipokines
K1 Gut microbiota
K1 Adipose-tissue
K1 Pulmonary-function
K1 Lung-function
K1 Inflammation
K1 Leptin
K1 Adiponectin
K1 Disease
K1 Risk
K1 Cell
AB Obesity and asthma are two chronic conditions that affect millions of people. Genetic and lifestyle factors such as diet, physical activity, and early exposure to micro-organisms are important factors that may contribute to the escalating prevalence of both conditions. The prevalence of asthma is higher in obese individuals. Recently, two major phenotypes of asthma with obesity have been described: one phenotype of early-onset asthma that is aggravated by obesity, and a second phenotype of later-onset asthma that predominantly affects women. Systemic inflammation and mechanical effect, both due to the expansion of the adipose tissue, have been proposed as the main reasons for the association between obesity and asthma. However, the mechanisms involved are not yet fully understood. Moreover, it has also been suggested that insulin resistance syndrome can have a role in the association between these conditions. The intestinal microbiota is an important factor in the development of the immune system, and can be considered a link between obesity and asthma. In the obese state, higher lipopolysaccharide (LPS) serum levels as a consequence of a microbiota dysbiosis have been found. In addition, changes in microbiota composition result in a modification of carbohydrate fermentation capacity, therefore modifying short chain fatty acid (SCFA) levels. The main objective of this review is to summarize the principal findings that link obesity and asthma.
PB Mdpi
YR 2017
FD 2017-07-01
LK http://hdl.handle.net/10668/19282
UL http://hdl.handle.net/10668/19282
LA en
DS RISalud
RD Apr 5, 2025