%0 Journal Article
%A Cubillos-Zapata, Carolina
%A Martínez-García, Miguel Ángel
%A Campos-Rodríguez, Francisco
%A Sánchez de la Torre, Manuel
%A Nagore, Eduardo
%A Martorell-Calatayud, Antonio
%A Hernández Blasco, Luis
%A Chiner Vives, Eusebi
%A Abad-Capa, Jorge
%A Montserrat, Josep María
%A Cabriada-Nuño, Valentín
%A Cano-Pumarega, Irene
%A Corral-Peñafiel, Jaime
%A Diaz-Cambriles, Trinidad
%A Mediano, Olga
%A Somoza-González, María
%A Dalmau-Arias, Joan
%A Almendros, Isaac
%A Farré, Ramón
%A López-Collazo, Eduardo
%A Gozal, David
%A García-Río, Francisco
%A Spanish Sleep Network
%T Soluble PD-L1 is a potential biomarker of cutaneous melanoma aggressiveness and metastasis in obstructive sleep apnoea patients.
%D 2019
%U http://hdl.handle.net/10668/13253
%X Obstructive sleep apnoea (OSA) upregulates the programmed cell death-1 receptor and its ligand (PD-L1) pathway, potentially compromising immunosurveillance. We compared circulating levels of soluble PD-L1 (sPD-L1) in patients with cutaneous melanoma according to the presence and severity of OSA, and evaluated relationships with tumour aggressiveness and invasiveness.In a multicentre observational study, 360 patients with cutaneous melanoma underwent sleep studies, and serum sPD-L1 levels were assayed using ELISA. Cutaneous melanoma aggressiveness indices included mitotic rate, Breslow index, tumour ulceration, Clark level and tumour stage, and sentinel lymph node (SLN) metastasis was recorded as a marker of invasiveness.sPD-L1 levels were higher in severe OSA compared to mild OSA or non-OSA patients. In OSA patients, sPD-L1 levels correlated with Breslow index and were higher in patients with tumour ulceration, advanced primary tumour stages or with locoregional disease. The incorporation of sPD-L1 to the classic risk factors to SLN metastasis led to net improvements in the classification of 27.3%.Thus, sPD-L1 levels are increased in melanoma patients with severe OSA, and, in addition, might serve as a potential biomarker of cutaneous melanoma aggressiveness and invasiveness in this group of subjects.
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