RT Journal Article
T1 The Role of Autophagy in White Adipose Tissue Function: Implications for Metabolic Health.
A1 Clemente-Postigo, Mercedes
A1 Tinahones, Alberto
A1 El Bekay, Rajaa
A1 Malagón, María M
A1 Tinahones, Francisco J
K1 adipocyte
K1 adipose tissue
K1 autophagy
K1 diabetes
K1 metabolism
K1 obesity
AB White adipose tissue (WAT) is a highly adaptive endocrine organ that continuously remodels in response to nutritional cues. WAT expands to store excess energy by increasing adipocyte number and/or size. Failure in WAT expansion has serious consequences on metabolic health resulting in altered lipid, glucose, and inflammatory profiles. Besides an impaired adipogenesis, fibrosis and low-grade inflammation also characterize dysfunctional WAT. Nevertheless, the precise mechanisms leading to impaired WAT expansibility are yet unresolved. Autophagy is a conserved and essential process for cellular homeostasis, which constitutively allows the recycling of damaged or long-lived proteins and organelles, but is also highly induced under stress conditions to provide nutrients and remove pathogens. By modulating protein and organelle content, autophagy is also essential for cell remodeling, maintenance, and survival. In this line, autophagy has been involved in many processes affected during WAT maladaptation, including adipogenesis, adipocyte, and macrophage function, inflammatory response, and fibrosis. WAT autophagy dysregulation is related to obesity and diabetes. However, it remains unclear whether WAT autophagy alteration in obese and diabetic patients are the cause or the consequence of WAT malfunction. In this review, current data regarding these issues are discussed, focusing on evidence from human studies.
SN 2218-1989
YR 2020
FD 2020-04-30
LK https://hdl.handle.net/10668/25246
UL https://hdl.handle.net/10668/25246
LA en
DS RISalud
RD Apr 17, 2025