TY - JOUR AU - Guasp, Pablo AU - Barnea, Eilon AU - González-Escribano, M Francisca AU - Jiménez-Reinoso, Anaïs AU - Regueiro, José R AU - Admon, Arie AU - López de Castro, José A PY - 2017 DO - 10.1074/jbc.M117.789180 UR - http://hdl.handle.net/10668/11136 T2 - The Journal of biological chemistry AB - A low-activity variant of endoplasmic reticulum aminopeptidase 1 (ERAP1), Hap10, is associated with the autoinflammatory disorder Behçet's disease (BD) in epistasis with HLA-B*51, which is the main risk factor for this disorder. The role of Hap10 in... LA - en KW - aminopeptidase KW - antigen presentation KW - antigen processing KW - mass spectrometry (MS) KW - peptides KW - proteomics KW - Aminopeptidases KW - Behcet Syndrome KW - Cell Line KW - HLA-B51 Antigen KW - Humans KW - Killer Cells, Natural KW - Minor Histocompatibility Antigens KW - Peptides KW - Polymorphism, Genetic KW - Protein Domains KW - T-Lymphocytes TI - The Behçet's disease-associated variant of the aminopeptidase ERAP1 shapes a low-affinity HLA-B*51 peptidome by differential subpeptidome processing. TY - research article VL - 292 ER -