RT Journal Article
T1 Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans.
A1 Liu, Kui
A1 Li, Quan-Zhen
A1 Delgado-Vega, Angelica M
A1 Abelson, Anna-Karin
A1 Sánchez, Elena
A1 Kelly, Jennifer A
A1 Li, Li
A1 Liu, Yang
A1 Zhou, Jinchun
A1 Yan, Mei
A1 Ye, Qiu
A1 Liu, Shenxi
A1 Xie, Chun
A1 Zhou, Xin J
A1 Chung, Sharon A
A1 Pons-Estel, Bernardo
A1 Witte, Torsten
A1 Ramón, Enrique de
A1 Bae, Sang-Cheol
A1 Barizzone, Nadia
A1 Sebastiani, Gian Domenico
A1 Merrill, Joan T
A1 Gregersen, Peter K
A1 Gilkeson, Gary G
A1 Kimberly, Robert P
A1 Vyse, Timothy J
A1 Kim, Il
A1 D'Alfonso, Sandra
A1 Martin, Javier
A1 Harley, John B
A1 Criswell, Lindsey A
A1 Wakeland, Edward K
A1 Alarcón-Riquelme, Marta E
A1 Mohan, Chandra
A1 Danieli, Maria Giovanna
A1 Galeazzi, Mauro
A1 Querini, Patrizia Rovere
A1 Migliaresi, Sergio
A1 Scherbarth, Hugo R
A1 Lopez, Jorge A
A1 Motta, Estela L
A1 Gamron, Susana
A1 Drenkard, Cristina
A1 Menso, Emilia
A1 Allievi, Alberto
A1 Tate, Guillermo A
A1 Presas, José L
A1 Palatnik, Simon A
A1 Abdala, Marcelo
A1 Bearzotti, Mariela
A1 Alvarellos, Alejandro
A1 Caeiro, Francisco
A1 Bertoli, Ana
A1 Paira, Sergio
A1 Roverano, Susana
A1 Graf, Cesar E
A1 Bertero, Estela
A1 Caprarulo, Cesar
A1 Buchanan, Griselda
A1 Guillerón, Carolina
A1 Grimaudo, Sebastian
A1 Manni, Jorge
A1 Catoggio, Luis J
A1 Soriano, Enrique R
A1 Santos, Carlos D
A1 Prigione, Cristina
A1 Ramos, Fernando A
A1 Navarro, Sandra M
A1 Berbotto, Guillermo A
A1 Jorfen, Marisa
A1 Romero, Elisa J
A1 Garcia, Mercedes A
A1 Marcos, Juan C
A1 Marcos, Ana I
A1 Perandones, Carlos E
A1 Eimon, Alicia
A1 Battagliotti, Cristina G
A1 Armadi-Simab, K
A1 Gross, Wolfgang L
A1 Gromnica-Ihle, Erika
A1 Peter, Hans-Hartmut
A1 Manger, Karin
A1 Schnarr, Sebastian
A1 Zeidler, Henning
A1 Schmidt, Reinhold E
A1 Ortego, Norberto
A1 Callejas, José L
A1 Jiménez-Alonso, Juan
A1 Sabio, Mario
A1 Sánchez-Román, Julio
A1 Garcia-Hernandez, Francisco J
A1 Camps, Mayte
A1 López-Nevot, Miguel Angel
A1 González-Escribano, Maria F
A1 Harley, John H
A1 Kimberly, Robert
A1 Criswell, Lindsey
A1 Langefeld, Carl
A1 Tsao, Betty
A1 Jacob, Chaim
K1 Animales
K1 Secuencia de Bases
K1 DNA
K1 Modelos animales de enfermedad
K1 Femenino
K1 Perfiles de expresión génica
K1 Membrana basal glomerular
K1 Humanos
K1 Calicreínas
K1 Lupus eritematoso sistémico
K1 Nefritis lúpica
K1 Ratones
K1 Ratones consanguíneos BALB C
K1 Ratones consanguíneos DBA
K1 Datos de Secuencia Molecular
K1 Análisis de secuencia de alineamiento de oligonucleótidos
K1 Polimorfismo genético
K1 Homología de Secuencia de Ácido Nucleico
K1 Especificidad de la Especie
AB Immune-mediated nephritis contributes to disease in systemic lupus erythematosus, Goodpasture syndrome (caused by antibodies specific for glomerular basement membrane [anti-GBM antibodies]), and spontaneous lupus nephritis. Inbred mouse strains differ in susceptibility to anti-GBM antibody-induced and spontaneous lupus nephritis. This study sought to clarify the genetic and molecular factors that maybe responsible for enhanced immune-mediated renal disease in these models. When the kidneys of 3 mouse strains sensitive to anti-GBM antibody-induced nephritis were compared with those of 2 control strains using microarray analysis, one-fifth of the underexpressed genes belonged to the kallikrein gene family,which encodes serine esterases. Mouse strains that upregulated renal and urinary kallikreins exhibited less evidence of disease. Antagonizing the kallikrein pathway augmented disease, while agonists dampened the severity of anti-GBM antibody-induced nephritis. In addition, nephritis-sensitive mouse strains had kallikrein haplotypes that were distinct from those of control strains, including several regulatory polymorphisms,some of which were associated with functional consequences. Indeed, increased susceptibility to anti-GBM antibody-induced nephritis and spontaneous lupus nephritis was achieved by breeding mice with a genetic interval harboring the kallikrein genes onto a disease-resistant background. Finally, both human SLE and spontaneous lupus nephritis were found to be associated with kallikrein genes, particularly KLK1 and the KLK3 promoter, when DNA SNPs from independent cohorts of SLE patients and controls were compared. Collectively, these studies suggest that kallikreins are protective disease-associated genes in anti-GBM antibody-induced nephritis and lupus.
PB American Society for Clinical Investigation
SN 0021-9738
YR 2009
FD 2009-04
LK http://hdl.handle.net/10668/816
UL http://hdl.handle.net/10668/816
LA en
NO Liu K, Li QZ, Delgado-Vega AM, Abelson AK, Sánchez E, Kelly JA, et al. Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans. J. Clin. Invest.. 2009 Apr; 119(4):911-23
NO Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 11, 2025