RT Journal Article
T1 Alterations in One-Carbon Metabolism in Celiac Disease.
A1 Martin-Masot, Rafael
A1 Mota-Martorell, Natalia
A1 Jove, Mariona
A1 Maldonado, Jose
A1 Pamplona, Reinald
A1 Nestares, Teresa
K1 Amino acids
K1 Celiac disease
K1 Choline
K1 Folate cycle
K1 Mass spectrometry
K1 Methionine cycle
K1 Methionine savage pathway
K1 Transsulfuration pathway
AB Celiac disease (CD) is an autoimmune enteropathy associated with alterations of metabolism. Metabolomics studies, although limited, showed changes in choline, choline-derived lipids, and methionine concentrations, which could be ascribed to alterations in one-carbon metabolism. To date, no targeted metabolomics analysis investigating differences in the plasma choline/methionine metabolome of CD subjects are reported. This work is a targeted metabolomic study that analyzes 37 metabolites of the one-carbon metabolism in 17 children with CD, treated with a gluten-free diet and 17 healthy control siblings, in order to establish the potential defects in this metabolic network. Our results demonstrate the persistence of defects in the transsulfuration pathway of CD subjects, despite dietary treatment, while choline metabolism, methionine cycle, and folate cycle seem to be reversed and preserved to healthy levels. These findings describe for the first time, a metabolic defect in one-carbon metabolism which could have profound implications in the physiopathology and treatment of CD.
PB MDPI
YR 2020
FD 2020-12-02
LK http://hdl.handle.net/10668/16734
UL http://hdl.handle.net/10668/16734
LA en
NO Martín-Masot R, Mota-Martorell N, Jové M, Maldonado J, Pamplona R, Nestares T. Alterations in One-Carbon Metabolism in Celiac Disease. Nutrients. 2020 Dec 2;12(12):3723
NO This research was funded by the Regional Government of Andalusia, Excellence Research Project No P12-AGR-2581, the Spanish Ministry of Science, Innovation, and Universities (Ministerio de Ciencia, Innovación y Universidades, RTI2018-099200-BI00), and the Generalitat of Catalonia: Agency for Management of University and Research Grants (2017SGR696), and Department of Health (SLT002/16/00250) to RP. This study was co-financed byFEDER funds from the European Union (“A way to build Europe”). IRBLleida is a CERCA Programme/Generalitat of Catalonia. It was also partially funded with the grant “Investigation grant program by the SPAO” 2020 edition.
DS RISalud
RD Apr 7, 2025