TY  - JOUR
AU  - Ibáñez-Costa, Alejandro
AU  - Gahete, Manuel D
AU  - Rivero-Cortés, Esther
AU  - Rincón-Fernández, David
AU  - Nelson, Richard
AU  - Beltrán, Manuel
AU  - de la Riva, Andrés
AU  - Japón, Miguel A
AU  - Venegas-Moreno, Eva
AU  - Gálvez, Ma Ángeles
AU  - García-Arnés, Juan A
AU  - Soto-Moreno, Alfonso
AU  - Morgan, Jennifer
AU  - Tsomaia, Natia
AU  - Culler, Michael D
AU  - Dieguez, Carlos
AU  - Castaño, Justo P
AU  - Luque, Raúl M
PY  - 2015
DO  - 10.1038/srep08714
UR  - http://hdl.handle.net/10668/2264
T2  - Scientific Reports
AB  - Pituitary adenomas comprise a heterogeneous subset of pathologies causing serious comorbidities, which would benefit from identification of novel, common molecular/cellular biomarkers and therapeutic targets. The ghrelin system has been linked to...
LA  - en
PB  - Nature Publishing Group
KW  - Adenoma
KW  - Corticotropina
KW  - Empalme alternativo
KW  - Animales
KW  - Apoptosis
KW  - Inmunotransferencia Western
KW  - Células CHO
KW  - Línea celular tumoral
KW  - Cricetinae
KW  - Cinasas MAP reguladas por señales extracelulares
KW  - Regulación de la expresión génica neoplásica
KW  - Ghrelina
KW  - Hormona del crecimiento
KW  - Humanos
KW  - Intrones
KW  - Datos de Secuencia Molecular
KW  - Péptidos
KW  - Neoplasias hipofisarias
KW  - Isoformas de proteínas
KW  - Proteínas protooncogénicas c-akt
KW  - Interferencia por ARN
KW  - Reacción en cadena de la polimerasa por transcriptasa inversa
KW  - Transducción de señales
KW  - Células tumorales cultivadas
KW  - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Adenoma
KW  - Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Pituitary Hormones::Pituitary Hormones, Anterior::Pro-Opiomelanocortin::Adrenocorticotropic Hormone
KW  - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Chemical Processes::Biochemical Processes::RNA Processing, Post-Transcriptional::RNA Splicing::Alternative Splicing
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Apoptosis
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Molecular Probe Techniques::Immunoassay::Immunoblotting::Blotting, Western
KW  - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::CHO Cells
KW  - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Cricetinae
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intracellular Signaling Peptides and Proteins::Mitogen-Activated Protein Kinases::Extracellular Signal-Regulated MAP Kinases
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Gene Expression Regulation, Neoplastic
KW  - Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Ghrelin
KW  - Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Pituitary Hormones::Pituitary Hormones, Anterior::Growth Hormone
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Gene Components::Introns
KW  - Medical Subject Headings::Information Science::Information Science::Information Services::Documentation::Molecular Sequence Data
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides
KW  - Medical Subject Headings::Diseases::Endocrine System Diseases::Pituitary Diseases::Pituitary Neoplasms
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Protein Isoforms
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Neoplasm Proteins::Oncogene Proteins::Proto-Oncogene Proteins::Proto-Oncogene Proteins c-akt
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Epigenesis, Genetic::Gene Silencing::RNA Interference
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Nucleic Acid Amplification Techniques::Polymerase Chain Reaction::Reverse Transcriptase Polymerase Chain Reaction
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Signal Transduction
KW  - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Tumor Cells, Cultured
TI  - In1-ghrelin splicing variant is overexpressed in pituitary adenomas and increases their aggressive features.
TY  - research article
ER  -