RT Journal Article
T1 HLA and non-HLA genes in Behçet's disease: a multicentric study in the Spanish population.
A1 Montes-Cano, Marco Antonio
A1 Conde-Jaldón, Marta
A1 García-Lozano, José Raul
A1 Ortiz-Fernández, Lourdes
A1 Ortego-Centeno, Norberto
A1 Castillo-Palma, María Jesús
A1 Espinosa, Gerard
A1 Graña-Gil, Genaro
A1 González-Gay, Miguel Ángel
A1 Barnosi-Marín, Ana Celia
A1 Solans, Roser
A1 Fanlo, Patricia
A1 Camps, Teresa
A1 Castañeda, Santos
A1 Sánchez-Bursón, Juan
A1 Núñez-Roldán, Antonio
A1 Martín, Javier
A1 González-Escribano, María Francisca
K1 HLA-A Antigens
K1 HLA-B Antigens
K1 HLA-B35 Antigen
K1 HLA-B51 Antigen
K1 HLA-B57 antigen
K1 IL23R protein, human
K1 Receptors, Interleukin
K1 Interleukin-10
K1 HLA Antigens
K1 Antígenos HLA-A
K1 Antígenos HLA-B
K1 Antígeno HLA-B35
K1 Antígeno HLA-B51
K1 Antígeno HLA-B57
K1 Antígeno HLA
K1 Receptores de Interleucina
K1 Interleucina-10
AB INTRODUCTIONAccording to genome wide association (GWA) studies as well as candidate gene approaches, Behçet's disease (BD) is associated with human leukocyte antigen (HLA)-A and HLA-B gene regions. The HLA-B51 has been consistently associated with the disease, but the role of other HLA class I molecules remains controversial. Recently, variants in non-HLA genes have also been associated with BD. The aims of this study were to further investigate the influence of the HLA region in BD and to explore the relationship with non-HLA genes recently described to be associated in other populations.METHODSThis study included 304 BD patients and 313 ethnically matched controls. HLA-A and HLA-B low resolution typing was carried out by PCR-SSOP Luminex. Eleven tag single nucleotide polymorphisms (SNPs) located outside of the HLA-region, previously described associated with the disease in GWA studies and having a minor allele frequency in Caucasians greater than 0.15 were genotyped using TaqMan assays. Phenotypic and genotypic frequencies were estimated by direct counting and distributions were compared using the χ(2) test.RESULTSIn addition to HLA-B*51, HLA-B*57 was found as a risk factor in BD, whereas, B*35 was found to be protective. Other HLA-A and B specificities were suggestive of association with the disease as risk (A*02 and A*24) or protective factors (A*03 and B*58). Regarding the non-HLA genes, the three SNPs located in IL23R and one of the SNPs in IL10 were found to be significantly associated with susceptibility to BD in our population.CONCLUSIONDifferent HLA specificities are associated with Behçet's disease in addition to B*51. Other non-HLA genes, such as IL23R and IL-10, play a role in the susceptibility to the disease.
PB BioMedCentral
SN 1478-6354
YR 2013
FD 2013
LK http://hdl.handle.net/10668/1863
UL http://hdl.handle.net/10668/1863
LA en
NO Montes-Cano MA, Conde-Jaldón M, García-Lozano JR, Ortiz-Fernández L, Ortego-Centeno N, Castillo-Palma MJ, et al. HLA and non-HLA genes in Behçet's disease: a multicentric study in the Spanish population. Arthritis Res. Ther. 2013; 15(5):R145
NO Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 5, 2025