TY - JOUR AU - Torres-Torrelo, Hortensia AU - Ortega-Sáenz, Patricia AU - Gao, Lin AU - López-Barneo, José PY - 2021 DO - 10.1038/s41467-021-24444-7 UR - http://hdl.handle.net/10668/4418 T2 - Nature Communications AB - Classically considered a by-product of anaerobic metabolism, lactate is now viewed as a fundamental fuel for oxidative phosphorylation in mitochondria, and preferred over glucose by many tissues. Lactate is also a signaling molecule of increasing... LA - en PB - Nature Publishing Group KW - Carotid body KW - Reactive oxygen species KW - Hypoxia KW - Mitochondria KW - Homeostasis KW - Lactate dehydrogenase KW - Chemoreceptor cells KW - Cation Channels KW - Cuerpo carotídeo KW - Especies reactivas de oxígeno KW - Hipoxia KW - Mitocondrias KW - Células quimiorreceptoras KW - Medical Subject Headings::Organisms::Eukaryota::Animals KW - Medical Subject Headings::Anatomy::Cardiovascular System::Blood Vessels::Arteries KW - Medical Subject Headings::Anatomy::Nervous System::Neurons::Neurons, Afferent::Sensory Receptor Cells::Chemoreceptor Cells::Paraganglia, Nonchromaffin::Carotid Body KW - Medical Subject Headings::Anatomy::Cells::Neurons::Neurons, Afferent::Sensory Receptor Cells::Chemoreceptor Cells KW - Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Homeostasis KW - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Hydrogen-Ion Concentration KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Membrane Transport Proteins::Ion Channels KW - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Carboxylic Acids::Hydroxy Acids::Lactates::Lactic Acid KW - Medical Subject Headings::Anatomy::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Mitochondria KW - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Phosphorylation KW - Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Oxygen Compounds::Reactive Oxygen Species KW - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Chemical Processes KW - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Membrane Potentials::Action Potentials KW - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Anaerobiosis KW - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Phosphorylation::Oxidative Phosphorylation KW - Medical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Movement::Motor Activity::Exercise KW - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Carboxylic Acids::Hydroxy Acids::Lactates KW - Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Sepsis TI - Lactate sensing mechanisms in arterial chemoreceptor cells TY - research article ER -