RT Journal Article
T1 A Gene Variation at the ZPR1 Locus (rs964184) Interacts With the Type of Diet to Modulate Postprandial Triglycerides in Patients With Coronary Artery Disease: From the Coronary Diet Intervention With Olive Oil and Cardiovascular Prevention Study.
A1 Alcala-Diaz, Juan F
A1 Arenas-de Larriva, Antonio P
A1 Torres-Peña, Jose D
A1 Rodriguez-Cantalejo, Fernando
A1 Rangel-Zuñiga, Oriol A
A1 Yubero-Serrano, Elena M
A1 Gutierrez-Mariscal, Francisco M
A1 Cardelo, Magdalena P
A1 Luque, Raul M
A1 Ordovas, Jose M
A1 Perez-Martinez, Pablo
A1 Delgado-Lista, Javier
A1 Lopez-Miranda, Jose
K1 SNP
K1 Coronary artery disease
K1 Diet
K1 Nutrigenetics
K1 Nutrigenomics
K1 Postprandial triglycerides
K1 Single nucleotide polymorphism
AB rs964184 variant in the ZPR1 gene has been associated with blood lipids levels both in fasting and postprandial state and with the risk of myocardial infarction in high-risk cardiovascular patients. However, whether this association is modulated by diet has not been studied. To investigate whether the type of diet (low-fat or Mediterranean diets) interacts with genetic variability at this loci to modulate fasting and postprandial lipids in coronary patients. The genotype of the rs964184 polymorphism was determined in the Cordioprev Study population (NCT00924937). Fasting and Postprandial triglycerides were assessed before and after 3 years of dietary intervention with either a Mediterranean or a low-fat diet. Postprandial lipid assessment was done by a 4-h oral fat tolerance test (OFTT). Differences in triglycerides levels were identified using repeated-measures ANCOVA. From 523 patients (85% males, mean age 59 years) that completed the OFTT at baseline and after 3 years of intervention and had complete genotype information, 125 of them were carriers of the risk allele G. At the start of the study, these patients showed a higher fasting and postprandial triglycerides (TG) plasma levels. After 3 years of dietary intervention, G-carriers following a Mediterranean Diet maintained higher fasting and postprandial triglycerides, while those on the low-fat diet reduced their postprandial triglycerides to similar values to the population without the G-allele. After 3 years of dietary intervention, the altered postprandial triglyceride response induced by genetic variability in the rs964184 polymorphism of the ZPR1 gene can be modulated by a low-fat diet, better than by a Mediterranean diet, in patients with coronary artery disease.
PB Frontiers Research Foundation
SN 2296-861X
YR 2022
FD 2022-05-09
LK http://hdl.handle.net/10668/20665
UL http://hdl.handle.net/10668/20665
LA en
NO Alcala-Diaz JF, Arenas-de Larriva AP, Torres-Peña JD, Rodriguez-Cantalejo F, Rangel-Zuñiga OA, Yubero-Serrano EM, et al. A Gene Variation at the ZPR1 Locus (rs964184) Interacts With the Type of Diet to Modulate Postprandial Triglycerides in Patients With Coronary Artery Disease: From the Coronary Diet Intervention With Olive Oil and Cardiovascular Prevention Study. Front Nutr. 2022 Jun 17;9:885256
DS RISalud
RD Apr 17, 2025