RT Journal Article
T1 The Role of MicroRNAs in Dilated Cardiomyopathy: New Insights for an Old Entity.
A1 Alonso-Villa, Elena
A1 Bonet, Fernando
A1 Hernandez-Torres, Francisco
A1 Campuzano, Oscar
A1 Sarquella-Brugada, Georgia
A1 Quezada-Feijoo, Maribel
A1 Ramos, Monica
A1 Mangas, Alipio
A1 Toro, Rocio
K1 Apoptosis
K1 Autophagia
K1 Dilated cardiomyopathy
K1 Etiology
K1 Fibrosis
K1 Inflammation
K1 MicroRNA
K1 Molecular pathways
K1 Oxidative stress
K1 Reticulum endoplasmic stress
AB Dilated cardiomyopathy (DCM) is a clinical diagnosis characterized by left ventricular or biventricular dilation and systolic dysfunction. In most cases, DCM is progressive, leading to heart failure (HF) and death. This cardiomyopathy has been considered a common and final phenotype of several entities. DCM occurs when cellular pathways fail to maintain the pumping function. The etiology of this disease encompasses several factors, such as ischemia, infection, autoimmunity, drugs or genetic susceptibility. Although the prognosis has improved in the last few years due to red flag clinical follow-up, early familial diagnosis and ongoing optimization of treatment, due to its heterogeneity, there are no targeted therapies available for DCM based on each etiology. Therefore, a better understanding of the mechanisms underlying the pathophysiology of DCM will provide novel therapeutic strategies against this cardiac disease and their different triggers. MicroRNAs (miRNAs) are a group of small noncoding RNAs that play key roles in post-transcriptional gene silencing by targeting mRNAs for translational repression or, to a lesser extent, degradation. A growing number of studies have demonstrated critical functions of miRNAs in cardiovascular diseases (CVDs), including DCM, by regulating mechanisms that contribute to the progression of the disease. Herein, we summarize the role of miRNAs in inflammation, endoplasmic reticulum (ER) stress, oxidative stress, mitochondrial dysfunction, autophagy, cardiomyocyte apoptosis and fibrosis, exclusively in the context of DCM.
PB MDPI
YR 2022
FD 2022-11-03
LK http://hdl.handle.net/10668/21213
UL http://hdl.handle.net/10668/21213
LA en
NO Alonso-Villa E, Bonet F, Hernandez-Torres F, Campuzano Ó, Sarquella-Brugada G, Quezada-Feijoo M, et a. The Role of MicroRNAs in Dilated Cardiomyopathy: New Insights for an Old Entity. Int J Mol Sci. 2022 Nov 5;23(21):13573
DS RISalud
RD Apr 11, 2025