TY  - JOUR
AU  - Liu, Xiao-Bo
AU  - Haney, Jillian R
AU  - Cantero, Gloria
AU  - Lambert, Jenna R
AU  - Otero-Garcia, Marcos
AU  - Truong, Brian
AU  - Gropman, Andrea
AU  - Cobos, Inma
AU  - Cederbaum, Stephen D
AU  - Lipshutz, Gerald S
PY  - 2019
DO  - 10.1172/jci.insight.130260
UR  - http://hdl.handle.net/10668/14472
T2  - JCI insight
AB  - Deficiency of arginase is associated with hyperargininemia, and prominent features include spastic diplegia/tetraplegia, clonus, and hyperreflexia; loss of ambulation, intellectual disability and progressive neurological decline are other signs. To...
LA  - en
KW  - Gene therapy
KW  - Genetic diseases
KW  - Neurodevelopment
KW  - Neuroscience
KW  - Animals
KW  - Arginase
KW  - Axons
KW  - Central Nervous System
KW  - Disease Models, Animal
KW  - Female
KW  - Gene Expression Profiling
KW  - Gene Expression Regulation
KW  - Genetic Predisposition to Disease
KW  - Genetic Therapy
KW  - Homozygote
KW  - Hyperargininemia
KW  - Liver
KW  - Male
KW  - Mice
KW  - Mice, Knockout
KW  - Oligodendroglia
KW  - Transcriptome
TI  - Hepatic arginase deficiency fosters dysmyelination during postnatal CNS development.
TY  - research article
VL  - 4
ER  -