RT Journal Article
T1 Diagnostic accuracy of noncontrast CT imaging markers in cerebral venous thrombosis.
A1 Buyck, Pieter-Jan
A1 Zuurbier, Susanna M
A1 Garcia-Esperon, Carlos
A1 Barboza, Miguel A
A1 Costa, Paolo
A1 Escudero, Irene
A1 Renard, Dimitri
A1 Lemmens, Robin
A1 Hinteregger, Nicole
A1 Fazekas, Franz
A1 Conde, Jordi Jimenez
A1 Giralt-Steinhauer, Eva
A1 Hiltunen, Sini
A1 Arauz, Antonio
A1 Pezzini, Alessandro
A1 Montaner, Joan
A1 Putaala, Jukka
A1 Weimar, Christian
A1 Churilov, Leonid
A1 Gattringer, Thomas
A1 Asadi, Hamed
A1 Tatlisumak, Turgut
A1 Coutinho, Jonathan M
A1 Demaerel, Philippe
A1 Thijs, Vincent
AB To assess the added diagnostic value of semiquantitative imaging markers on noncontrast CT scans in cerebral venous thrombosis (CVT). In a retrospective, multicenter, blinded, case-control study of patients with recent onset ( We enrolled 285 patients with CVT and 303 controls from 10 international centers. Sensitivity of visual impression of thrombosis ranged from 41% to 73% and specificity ranged from 97% to 100%. Attenuation measurement had an area under the curve (AUC) of 0.78 (95% confidence interval [CI] 0.74-0.81). After adjustment for hematocrit, the AUC remained 0.78 (95% CI 0.74-0.81). The analysis of attenuation ratios of affected vs unaffected sinuses had AUC of 0.83 (95% CI 0.8-0.86). Adding this imaging marker significantly improved discrimination, but sensitivity when tolerating a false-positive rate of 20% was not higher than 76% (95% CI 0.70-0.81). Semiquantitative analysis of attenuation values for diagnosis of CVT increased sensitivity but still failed to identify 1 out of 4 CVT. This study provides Class II evidence that visual analysis of plain CT with or without attenuation measurements has high specificity but only moderate sensitivity for CVT.
YR 2019
FD 2019-01-18
LK http://hdl.handle.net/10668/13433
UL http://hdl.handle.net/10668/13433
LA en
DS RISalud
RD Apr 18, 2025