%0 Journal Article
%A Buyck, Pieter-Jan
%A Zuurbier, Susanna M
%A Garcia-Esperon, Carlos
%A Barboza, Miguel A
%A Costa, Paolo
%A Escudero, Irene
%A Renard, Dimitri
%A Lemmens, Robin
%A Hinteregger, Nicole
%A Fazekas, Franz
%A Conde, Jordi Jimenez
%A Giralt-Steinhauer, Eva
%A Hiltunen, Sini
%A Arauz, Antonio
%A Pezzini, Alessandro
%A Montaner, Joan
%A Putaala, Jukka
%A Weimar, Christian
%A Churilov, Leonid
%A Gattringer, Thomas
%A Asadi, Hamed
%A Tatlisumak, Turgut
%A Coutinho, Jonathan M
%A Demaerel, Philippe
%A Thijs, Vincent
%T Diagnostic accuracy of noncontrast CT imaging markers in cerebral venous thrombosis.
%D 2019
%U http://hdl.handle.net/10668/13433
%X To assess the added diagnostic value of semiquantitative imaging markers on noncontrast CT scans in cerebral venous thrombosis (CVT). In a retrospective, multicenter, blinded, case-control study of patients with recent onset ( We enrolled 285 patients with CVT and 303 controls from 10 international centers. Sensitivity of visual impression of thrombosis ranged from 41% to 73% and specificity ranged from 97% to 100%. Attenuation measurement had an area under the curve (AUC) of 0.78 (95% confidence interval [CI] 0.74-0.81). After adjustment for hematocrit, the AUC remained 0.78 (95% CI 0.74-0.81). The analysis of attenuation ratios of affected vs unaffected sinuses had AUC of 0.83 (95% CI 0.8-0.86). Adding this imaging marker significantly improved discrimination, but sensitivity when tolerating a false-positive rate of 20% was not higher than 76% (95% CI 0.70-0.81). Semiquantitative analysis of attenuation values for diagnosis of CVT increased sensitivity but still failed to identify 1 out of 4 CVT. This study provides Class II evidence that visual analysis of plain CT with or without attenuation measurements has high specificity but only moderate sensitivity for CVT.
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