RT Journal Article
T1 COVID-19 Vaccines and Autoimmune Hematologic Disorders.
A1 Mingot-Castellano, Maria Eva
A1 Butta, Nora
A1 Canaro, Mariana
A1 Gomez-Del-Castillo-Solano, Maria Del Carmen
A1 Sanchez-Gonzalez, Blanca
A1 Jimenez-Barcenas, Reyes
A1 Pascual-Izquierdo, Cristina
A1 Caballero-Navarro, Gonzalo
A1 Entrena-Ureña, Laura
A1 Gonzalez-Lopez, Tomas Jose
K1 AIHA and Evans syndrome
K1 COVID-19
K1 ITP
K1 TTP
K1 VITT
K1 antiphospholipid syndrome
K1 catastrophic antiphospholipid syndrome
K1 vaccines
AB Worldwide vaccination against SARS-CoV-2 has allowed the detection of hematologic autoimmune complications. Adverse events (AEs) of this nature had been previously observed in association with other vaccines. The underlying mechanisms are not totally understood, although mimicry between viral and self-antigens plays a relevant role. It is important to remark that, although the incidence of these AEs is extremely low, their evolution may lead to life-threatening scenarios if treatment is not readily initiated. Hematologic autoimmune AEs have been associated with both mRNA and adenoviral vector-based SARS-CoV-2 vaccines. The main reported entities are secondary immune thrombocytopenia, immune thrombotic thrombocytopenic purpura, autoimmune hemolytic anemia, Evans syndrome, and a newly described disorder, so-called vaccine-induced immune thrombotic thrombocytopenia (VITT). The hallmark of VITT is the presence of anti-platelet factor 4 autoantibodies able to trigger platelet activation. Patients with VITT present with thrombocytopenia and may develop thrombosis in unusual locations such as cerebral beds. The management of hematologic autoimmune AEs does not differ significantly from that of these disorders in a non-vaccine context, thus addressing autoantibody production and bleeding/thromboembolic risk. This means that clinicians must be aware of their distinctive signs in order to diagnose them and initiate treatment as soon as possible.
PB MDPI AG
SN 2076-393X
YR 2022
FD 2022-06-16
LK http://hdl.handle.net/10668/21609
UL http://hdl.handle.net/10668/21609
LA en
NO Mingot-Castellano ME, Butta N, Canaro M, Gómez Del Castillo Solano MDC, Sánchez-González B, Jiménez-Bárcenas R, et al. COVID-19 Vaccines and Autoimmune Hematologic Disorders. Vaccines (Basel). 2022 Jun 16;10(6):961.
DS RISalud
RD May 12, 2025