RT Journal Article
T1 Protective Effects of Probiotic Consumption in Cardiovascular Disease in Systemic Lupus Erythematosus.
A1 de la Visitacion, Nestor
A1 Robles-Vera, Iñaki
A1 Toral, Marta
A1 Duarte, Juan
K1 endothelial dysfunction
K1 gut microbiota
K1 hypertension
K1 immune response
K1 nephritis
AB The prevalence of renal and cardiovascular disease (CVD) in patients with systemic lupus erythematosus (SLE) is higher than in general populations. Recently, a causal role of gut microbiota on the development of immune responses in SLE has been described. Probiotic consumption changes the composition of gut microbiota, preventing SLE progression. The aim of this review is to explore the role of the gut microbiota in the development of renal and cardiovascular disease in SLE and how probiotics could be a therapeutic option. Despite strong evidence on the beneficial effects of probiotics in the development of autoimmunity and nephritis in SLE, only a few studies described the protective effects of Lactobacillus in important risk factors for CVD, such as endothelial dysfunction and hypertension in mice. The preventive effects of probiotics in renal and CVD in humans have not been established yet.
PB MDPI AG
YR 2019
FD 2019-10-28
LK http://hdl.handle.net/10668/14643
UL http://hdl.handle.net/10668/14643
LA en
NO de la Visitación N, Robles-Vera I, Toral M, Duarte J. Protective Effects of Probiotic Consumption in Cardiovascular Disease in Systemic Lupus Erythematosus. Nutrients. 2019 Nov 5;11(11):2676.
NO This work was supported by grants from Comisión Interministerial de Ciencia y Tecnología, Ministerio de Economía y competitividad (MINECO) (SAF2014-55523-R, SAF2017-84894-R) and Junta de Andalucía (Proyecto de excelencia P12-CTS-2722, and CTS 164), with funds from the European Union, and by the Ministerio de Economia y Competitividad, Instituto de Salud Carlos III (CIBER-CV). I.R.-V. is a predoctoral fellow of MINECO; N.d.l.V. is a predoctoral fellow of Junta de Andalucía and Fondo Social Europeo “FEDER una manera de hacer Europa”, and M.T. is a postdoctoral fellow of Instituto de Salud Carlos III (Sara Borrell Program).
DS RISalud
RD May 10, 2025