RT Journal Article
T1 Inflammatory Cascade in Alzheimer's Disease Pathogenesis: A Review of Experimental Findings
A1 de Oliveira, Jade
A1 Kucharska, Ewa
A1 Garcez, Michelle Lima
A1 Rodrigues, Matheus Scarpatto
A1 Quevedo, João
A1 Moreno-Gonzalez, Ines
A1 Budni, Josiane
K1 Alzheimer’s disease
K1 Neurodegenerative disease
K1 Dementia
K1 Neuroinflammation
K1 Inflammatory cascade
K1 Systemic inflammation
K1 BBB disruption
K1 Anti-inflammatory effects
K1 Therapy
K1 Enfermedad de Alzheimer
K1 Enfermedades neurodegenerativas
K1 Demencia
K1 Terapéutica
K1 Síndrome de respuesta inflamatoria sistémica
AB Alzheimer's disease (AD) is the leading cause of dementia worldwide. Most AD patients develop the disease in late life, named late onset AD (LOAD). Currently, the most recognized explanation for AD pathology is the amyloid cascade hypothesis. It is assumed that amyloid beta (Aβ) aggregation and deposition are critical pathogenic processes in AD, leading to the formation of amyloid plaques, as well as neurofibrillary tangles, neuronal cell death, synaptic degeneration, and dementia. In LOAD, the causes of Aβ accumulation and neuronal loss are not completely clear. Importantly, the blood-brain barrier (BBB) disruption seems to present an essential role in the induction of neuroinflammation and consequent AD development. In addition, we propose that the systemic inflammation triggered by conditions like metabolic diseases or infections are causative factors of BBB disruption, coexistent inflammatory cascade and, ultimately, the neurodegeneration observed in AD. In this regard, the use of anti-inflammatory molecules could be an interesting strategy to treat, delay or even halt AD onset and progression. Herein, we review the inflammatory cascade and underlying mechanisms involved in AD pathogenesis and revise the anti-inflammatory effects of compounds as emerging therapeutic drugs against AD.
PB MDPI
YR 2021
FD 2021-09-28
LK http://hdl.handle.net/10668/3613
UL http://hdl.handle.net/10668/3613
LA en
NO de Oliveira J, Kucharska E, Garcez ML, Rodrigues MS, Quevedo J, Moreno-Gonzalez I, et al. Inflammatory Cascade in Alzheimer's Disease Pathogenesis: A Review of Experimental Findings. Cells. 2021 Sep 28;10(10):2581
DS RISalud
RD Apr 5, 2025