RT Journal Article
T1 Characterization of lipid profile by nuclear magnetic resonance spectroscopy (1H NMR) of metabolically healthy obese women after weight loss with Mediterranean diet and physical exercise.
A1 Rodriguez-Garcia, Enrique
A1 Ruiz-Nava, Josefina
A1 Santamaria-Fernandez, Sonia
A1 Fernandez-Garcia, Jose Carlos
A1 Vargas-Candela, Antonio
A1 Yahyaoui, Raquel
A1 Tinahones, Francisco J
A1 Bernal-Lopez, Maria Rosa
A1 Gomez-Huelgas, Ricardo
K1 Lipid profile
K1 Mediterranean diet
K1 Metabolically healthy obese
K1 Nuclear magnetic resonance spectroscopy
K1 Physical exercise
AB Obesity is associated with an atherogenic lipid profile. No data exists on lipoprotein particle profiles in metabolically healthy obese (MHO) individuals. Our aim is to characterize lipoprotein size, particle, and subclass concentrations in MHO women after 3 months of weight loss through dietary restriction and physical exercise. A total of 115 nondiabetic women (aged 35–55 years) with a body mass index (BMI) of 30 to 40 kg/m² and one of the following criteria: blood pressure 135/85 mmHg, fasting plasma glucose 100 mg/dL, HDL-cholesterol 50 mg/dL, and triglycerides 150 mg/dL were included. After 3 months of intensive lifestyle modification (Mediterranean diet and physical exercise), they were classified according to their weight loss: <5%, ≥5% to <10%, and ≥10%. Lipoprotein size, particle, and subclass concentrations were measured using 1H NMR. The final sample, after dropouts, comprised 104 women (age: 44.4±3.7 years, BMI: 36.3±4.7 kg/m²), of whom 47 (45.2%), 27 (26%), and 30 (28.8%) lost <5%, ≥5% to <10%, and ≥10% of baseline body weight, respectively. All participants experienced significant weight loss and decreases in BMI. The lipid profiles showed an increase in small, medium, and large very low-density lipoprotein (VLDL) particles in all groups of study with the exception of small VLDL particles in women with ≥10% of weight loss, in which it decreased. The number of VLDL particles decreased in women who had ≥10% weight loss. On the other hand, we detected a decrease in all low-density lipoprotein (cLDL) and high-density lipoprotein (cHDL) concentrations. These results indicate that intensive lifestyle modification alters lipid profiles. In particular, it decreases small LDL and HDL particle numbers and does not increase medium or large HDL particle numbers. Abbreviations: 1H NMR = nuclear magnetic resonance spectroscopy, cHDL = high-density lipoproteins bound to cholesterol, cLDL = low-density lipoproteins bound to cholesterol, CVD = cardiovascular disease, CVR = cardiovascular risk, IDL = intermediate density lipoprotein, MHO = metabolically healthy obese, VLDL = very low-density lipoprotein.
PB Wolters Kluwer Health
YR 2017
FD 2017-05-10
LK http://hdl.handle.net/10668/11378
UL http://hdl.handle.net/10668/11378
LA en
NO Rodriguez-Garcia E, Ruiz-Nava J, Santamaria-Fernandez S, Fernandez-Garcia JC, Vargas-Candela A, Yahyaoui R, et al. Characterization of lipid profile by nuclear magnetic resonance spectroscopy (1H NMR) of metabolically healthy obese women after weight loss with Mediterranean diet and physical exercise. Medicine (Baltimore). 2017 Jul;96(27):e7040
NO This work was supported by grants from the Instituto de Salud Carlos III, cofinanced by the Fondo Europeo de Desarrollo Regional-FEDER (PI12/01373 and “Centros de Investigación En Red” (CIBER, CB06/03/0018)), and M Rosa Bernal-Lopez was supported by “Miguel Servet Type I” program (CP15/00028) from the ISCIII-Madrid (Spain), cofinanced by the Fondo Europeo de Desarrollo Regional-FEDER.
DS RISalud
RD Apr 18, 2025