RT Journal Article
T1 Acute onset movement disorders in diabetes mellitus: A clinical series of 59 patients.
A1 Dubey, Souvik
A1 Chatterjee, Subhankar
A1 Ghosh, Ritwik
A1 Louis, Elan D
A1 Hazra, Avijit
A1 Sengupta, Samya
A1 Das, Shambaditya
A1 Banerjee, Abhirup
A1 Pandit, Alak
A1 Ray, Biman Kanti
A1 Benito-León, Julián
K1 Choreoballism
K1 Diabetes mellitus
K1 Diabetic striatopathy
K1 Hyperglycemia
K1 Movement disorders
AB No previous study has assessed the frequency and clinical-radiological characteristics of patients with diabetes mellitus (DM) and acute onset nonchoreic and nonballistic movements. We conducted a prospective study to investigate the spectrum of acute onset movement disorders in DM. We recruited all the patients with acute onset movement disorders and hyperglycemia who attended the wards of three hospitals in West Bengal, India from August 2014 to July 2021. Among the 59 patients (mean age = 55.4 ± 14.3 years, 52.5% men) who were included, 41 (69.5%) had choreic or ballistic movements, and 18 (30.5%) had nonchoreic and nonballistic movements. Ballism was the most common movement disorder (n = 18, 30.5%), followed by pure chorea (n = 15, 25.4%), choreoathetosis (n = 8, 13.6%), tremor (n = 5, 8.5%), hemifacial spasm (n = 3, 5.1%), parkinsonism (n = 3, 5.1%), myoclonus (n = 3, 5.1%), dystonia (n = 2, 3.4%), and restless leg syndrome (n = 2, 3.4%). The mean duration of DM was 9.8 ± 11.4 years (89.8% of the patients had type 2 DM). Nonketotic hyperglycemia was frequently (76.3%) detected. The majority (55.9%) had no magnetic resonance imaging (MRI) changes; the remaining showed striatal hyperintensity. Eight patients with MRI changes exhibited discordance with sidedness of movements. Most of the patients (76.3%) recovered completely. This is the largest clinical series depicting the clinical-radiological spectrum of acute onset movement disorders in DM. Of note was that almost one third of patients had nonchoreic and nonballistic movements. Our findings highlight the importance of a capillary blood glucose measurement in patients with acute or subacute onset movement disorders, irrespective of their past glycemic status.
YR 2022
FD 2022-04-28
LK http://hdl.handle.net/10668/19951
UL http://hdl.handle.net/10668/19951
LA en
DS RISalud
RD Apr 19, 2025