RT Generic T1 Effect of Physical Therapy Modalities on Quality of Life of Head and Neck Cancer Survivors: A Systematic Review with Meta-Analysis A1 Burgos-Mansilla, Barbara A1 Galiano-Castillo, Noelia A1 Lozano-Lozano, Mario A1 Fernandez-Lao, Carolina A1 Lopez-Garzon, Maria A1 Arroyo-Morales, Manuel K1 systematic review K1 meta-analysis K1 head and neck neoplasms K1 cancer survivors K1 physical therapy modalities K1 quality of life K1 Randomized controlled-trial K1 Upper-limb dysfunction K1 Exercise therapy K1 Shoulder dysfunction K1 Induced xerostomia K1 Nerve-stimulation K1 Induced trismus K1 Interventions K1 Radiotherapy K1 Dissection AB The objective was to describe the effectiveness of different physical therapy modalities to improve Quality of Life (QoL) in Head and Neck Cancer (HNC) survivors. PubMed, Scopus, Web of Science, CINAHL and Cochrane Library were searched for randomized clinical controlled trials published until 30 April 2020. Risk of bias assessment and meta-analysis were conducted using the Cochrane tools. A total of 251 records were retrieved, and 10 met the inclusion criteria. Interventions whose parameters focus on a 12-week exercise programs of aerobic activity (walking) or Progressive Resistance Training (PRT) for the whole body are effective and safe modalities improving QoL in HNC survivors. Electrophysical agents did not show significant results between groups. As for the assessment of methodological quality, 4 of the 10 articles included had a high risk of overall bias. Only five articles provided sufficient information to conduct a meta-analysis for exercise program intervention on QoL, showing a tendency in favor of intervention group, even when the global results did not show statistically significant improvements (pooled Cohen's d 0.15; 95% CI: -0.25 to 0.54; I-2 45.87%; p heterogeneity = 0.10). The present review and meta-analysis identified meaningful benefits of exercise on QoL of HNC survivors; this has been confirmed in a meta-analysis. This review adds evidence supporting exercise interventions on Head and Neck Cancer population whose opportunities for successful recovery after medical treatment are more limited. PB Mdpi YR 2021 FD 2021-10-01 LK https://hdl.handle.net/10668/28057 UL https://hdl.handle.net/10668/28057 LA en DS RISalud RD Apr 17, 2025