RT Journal Article
T1 No evidence of brown adipose tissue activation after 24 weeks of supervised exercise training in young sedentary adults in the ACTIBATE randomized controlled trial.
A1 Martinez-Tellez, Borja
A1 Sanchez-Delgado, Guillermo
A1 Acosta, Francisco M
A1 Alcantara, Juan M A
A1 Amaro-Gahete, Francisco J
A1 Martinez-Avila, Wendy D
A1 Merchan-Ramirez, Elisa
A1 Muñoz-Hernandez, Victoria
A1 Osuna-Prieto, Francisco J
A1 Jurado-Fasoli, Lucas
A1 Xu, Huiwen
A1 Ortiz-Alvarez, Lourdes
A1 Arias-Tellez, Maria J
A1 Mendez-Gutierrez, Andrea
A1 Labayen, Idoia
A1 Ortega, Francisco B
A1 Schönke, Milena
A1 Rensen, Patrick C N
A1 Aguilera, Concepcion M
A1 Llamas-Elvira, Jose M
A1 Gil, Angel
A1 Ruiz, Jonatan R
K1 Resistance Training
K1 Control Groups
K1 Disease Models, Animal
K1 Random Allocation
K1 Exercise Therapy
K1 Control Groups
AB Exercise modulates both brown adipose tissue (BAT) metabolism and white adipose tissue (WAT) browning in murine models. Whether this is true in humans, however, has remained unknown. An unblinded randomized controlled trial (ClinicalTrials.gov ID: NCT02365129) was therefore conducted to study the effects of a 24-week supervised exercise intervention, combining endurance and resistance training, on BAT volume and activity (primary outcome). The study was carried out in the Sport and Health University Research Institute and the Virgen de las Nieves University Hospital of the University of Granada (Spain). One hundred and forty-five young sedentary adults were assigned to either (i) a control group (no exercise, n = 54), (ii) a moderate intensity exercise group (MOD-EX, n = 48), or (iii) a vigorous intensity exercise group (VIG-EX n = 43) by unrestricted randomization. No relevant adverse events were recorded. 97 participants (34 men, 63 women) were included in the final analysis (Control; n = 35, MOD-EX; n = 31, and VIG-EX; n = 31). We observed no changes in BAT volume (Δ Control: -22.2 ± 52.6 ml; Δ MOD-EX: -15.5 ± 62.1 ml, Δ VIG-EX: -6.8 ± 66.4 ml; P = 0.771) or 18F-fluorodeoxyglucose uptake (SUVpeak Δ Control: -2.6 ± 3.1 ml; Δ MOD-EX: -1.2 ± 4.8, Δ VIG-EX: -2.2 ± 5.1; p = 0.476) in either the control or the exercise groups. Thus, we did not find any evidence of an exercise-induced change on BAT volume or activity in young sedentary adults.
PB Nature Publishing Group
YR 2022
FD 2022-08-02
LK http://hdl.handle.net/10668/19544
UL http://hdl.handle.net/10668/19544
LA en
NO Martinez-Tellez B, Sanchez-Delgado G, Acosta FM, Alcantara JMA, Amaro-Gahete FJ, Martinez-Avila WD, et al. No evidence of brown adipose tissue activation after 24 weeks of supervised exercise training in young sedentary adults in the ACTIBATE randomized controlled trial. Nat Commun. 2022 Sep 12;13(1):5259.
NO The authors thank all the participants who took part in the study, as well as those researchers who contributed to the study design (Drs. Barbara Cannon, Jan Nedergaard, José A Lopez Calbet, John Blundell, Graham Finlayson, Catherine Gibbons, Jose Antonio Jimenez-Rios, Emilio Martinez de Vitoria, and Maria Dolores Ruiz), data collection (Dr. Carlos de Teresa, Socorro Navarrete, Rosa Lozano, Esther Brea, Dr. Jose Rubio Lopez, Dr. Jose M Pascual, Dr. Josune Olza, Dr. Francisco Ruiz Ojeda, Amalia Cano Nieto, María Ruiz Ruiz, Laura Frutos, Marina Bórrallo, Miguel Angel Contreras Gomez, Juan Prados-Ruiz, Abdel-Karim Ruiz, Dr. Yolanda García Rivero, and Dr. Ángel Ramirez Navarro), and to the discussion of the results (Brooks Leitner and Dr. Mariëtte Boon). This study was funded by the Spanish Ministry of Economy and Competitiveness via the Fondo de Investigación Sanitaria del Instituto de Salud Carlos III (PI13/01393; J.R.R.) and PTA-12264I, Retos de la Sociedad (DEP2016-79512-R; J.R.R.) and European Regional Development Funds (ERDF; J.R.R.), the Spanish Ministry of Education (FPU13/04365 (G.S.D.), FPU14/04172 (F.A.G.), FPU15/04059 (J.M.A.), FPU16/03653 (A.M.G.), FPU16/02828 (F.J.O.P.), FPU16/05159 (H.X.), FPU17/01523 (L.O.A.), FPU19/01609 (L.J.F.)), International Doctoral Studies Scholarship no. 440575 from the Mexican National Council of Science and Technology (CONACYT; WDMA), the Fundación Iberoamericana de Nutrición (FINUT; JRR), the Redes Temáticas de Investigación Cooperativa RETIC (Red SAMID RD16/0022; J.R.R.), the AstraZeneca HealthCare Foundation (J.R.R.), the University of Granada Plan Propio de Investigación 2016 -Excellence actions: Unit of Excellence on Exercise and Health (UCEES) (J.R.R.)- and Plan Propio de Investigación 2018 - Programa Contratos-Puente and Programa Perfecionamiento de Doctores (G.S.D.), the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades (ERDF; ref. SOMM17/6107/UGR; JRR), the Junta de Andalucía, Consejería de Economía, Conocimiento, Empresas y Universidad (ref. P18-RT-4455; J.R.R.), the Fundación Alfonso Martín Escudero (B.M.T. and G.S.D.), the Maria Zambrano fellowship by the Ministerio de Universidades y la Unión Europea–NextGenerationEU (RR_C_2021_04; B.M.T.), and the Novo Nordisk Foundation (NNF18OC0032394; M.S.). This study was performed as part of a PhD thesis conducted within the Biomedicine Doctoral Studies Program of the University of Granada, Spain. The funding agencies had no role in study design, data collection and analysis or manuscript writing.
DS RISalud
RD Apr 7, 2025