TY  - JOUR
AU  - Schellenberg, Matthew J
AU  - Appel, C Denise
AU  - Riccio, Amanda A
AU  - Butler, Logan R
AU  - Krahn, Juno M
AU  - Liebermann, Jenna A
AU  - Cortés-Ledesma, Felipe
AU  - Williams, R Scott
PY  - 2020
DO  - 10.1093/nar/gkaa318
UR  - http://hdl.handle.net/10668/15476
T2  - Nucleic acids research
AB  - Tyrosyl-DNA phosphodiesterase 2 (TDP2) reverses Topoisomerase 2 DNA-protein crosslinks (TOP2-DPCs) in a direct-reversal pathway licensed by ZATTZNF451 SUMO2 E3 ligase and SUMOylation of TOP2. TDP2 also binds ubiquitin (Ub), but how Ub regulates TDP2...
LA  - en
KW  - Binding Sites
KW  - Catalytic Domain
KW  - Crystallography, X-Ray
KW  - DNA
KW  - DNA Topoisomerases, Type II
KW  - DNA-Binding Proteins
KW  - Humans
KW  - Models, Molecular
KW  - Mutation
KW  - Phosphoric Diester Hydrolases
KW  - Polyubiquitin
KW  - Protein Binding
KW  - Small Ubiquitin-Related Modifier Proteins
KW  - Substrate Specificity
KW  - Sumoylation
KW  - Ubiquitin
TI  - Ubiquitin stimulated reversal of topoisomerase 2 DNA-protein crosslinks by TDP2.
TY  - research article
VL  - 48
ER  -