RT Journal Article
T1 Medication-related factors associated with health-related quality of life in patients older than 65 years with polypharmacy.
A1 Montiel-Luque, Alonso
A1 Nuñez-Montenegro, Antonio Jesus
A1 Martin-Aurioles, Esther
A1 Canca-Sanchez, Jose Carlos
A1 Toro-Toro, Maria Carmen
A1 Gonzalez-Correa, Jose Antonio
K1 Quality of life
K1 Medical risk factors
K1 Cognitive impairment
K1 Drug therapy
K1 Mental health and psychiatry
K1 Drug administration
K1 Geriatric care
K1 Drug dependence
AB Objective: To describe the relationship between medication-related factors and the health-related quality of life in patients older than 65 years who use multiple medications (polypharmacy). Design: Cross-sectional descriptive study. Setting: Primary care. Participants: Patients older than 65 years who use multiple medications (n = 375). Measurements: The main outcome measure was health-related quality of life according to the EuroQol-5D instrument. Sociodemographic, clinical and medication-related variables were recorded during home interviews. Mean age was 74.72 ± 5.59 years, and 65.5% of our participants were women. The global level of health-related quality of life according to the EQ-5D visual analog scale was 59.25 ± 20.92. Of the five EuroQol dimensions, anxiety/depression and pain were the most frequently reported, while mobility and self-care were the dimensions with the greatest impact on self-reported quality of life. Multivariate analysis indicated that functional independence was the factor most strongly associated (β = 14.27 p < 0.001) with better health-related quality of life, while illiteracy (β = -13.58 p < 0.001), depression (β = -10.13 p < 0.001), social risk (β = -7.23 p = 0.004) and using more than 10 medicines (β = -4.85 p = 0.009) were strongly associated with a poorer health-related quality of life. Factors inherent within the patient such as functional incapacity, cognitive impairment and social and emotional problems were the main constraints to quality of life in our study population. The number of medicines taken was negatively related with quality of life.
PB Public Library of Science
YR 2017
FD 2017-02-06
LK http://hdl.handle.net/10668/10846
UL http://hdl.handle.net/10668/10846
LA en
NO Montiel-Luque A, Núñez-Montenegro AJ, Martín-Aurioles E, Canca-Sánchez JC, Toro-Toro MC, González-Correa JA; et al. Medication-related factors associated with health-related quality of life in patients older than 65 years with polypharmacy. PLoS One. 2017 Feb 6;12(2):e0171320.
DS RISalud
RD Oct 24, 2025