TY  - JOUR
AU  - Sastre, J.
AU  - García-Alfonso, P.
AU  - Viéitez, J. M.
AU  - Cano, M. T.
AU  - Rivera, F.
AU  - Reina-Zoilo, J. J.
AU  - Salud-Salvia, A.
AU  - Quintero, G.
AU  - Robles-Díaz, L
AU  - Safont, M. J.
AU  - La Casta, A.
AU  - Gil, S.
AU  - Polo, E.
AU  - Asensio-Martínez, E.
AU  - García-Paredes, B.
AU  - López, R. L.
AU  - Guillot, M.
AU  - Valladares-Ayerbes, M.
AU  - Aranda, E.
AU  - Díaz-Rubio, E.
PY  - 2021
DO  - 10.1016/j.esmoop.2021.100062
UR  - http://hdl.handle.net/10668/3917
T2  - ESMO Open
AB  - Background: We explored the influence of BRAF and PIK3CA mutational status on the efficacy of bevacizumab or cetuximab plus 5-fluorouracil/leucovorin and irinotecan (FOLFIRI) as first-line therapy in patients with RAS wild-type metastatic colorectal...
LA  - en
PB  - Elsevier Ltd on behalf of European Society for Medical Oncology
KW  - BRAF
KW  - Colorectal cancer
KW  - PIK3CA
KW  - RAS
KW  - Targeted therapy
KW  - Neoplasias colorrectales
KW  - Terapia dirigida
KW  - Neoplastic cells circulating
KW  - Células neoplásicas circulantes
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Antineoplastic Protocols::Antineoplastic Combined Chemotherapy Protocols
KW  - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Alkaloids::Camptothecin
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Phosphatidylinositol 3-Kinases::Phosphatidylinositol 3-Kinase::Class I Phosphatidylinositol...
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Serine-Threonine Kinases::MAP Kinase Kinase Kinases::raf...
KW  - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms
KW  - Medical Subject Headings::Diseases::Neoplasms::Neoplastic Processes::Neoplasm Metastasis::Neoplastic Cells, Circulating
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Coenzymes::Tetrahydrofolates::Formyltetrahydrofolates::Leucovorin
KW  - Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Asthenia
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Confidence Intervals
KW  - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Pyrimidines::Pyrimidinones::Uracil::Fluorouracil
KW  - Medical Subject Headings::Diseases::Hemic and Lymphatic Diseases::Hematologic Diseases::Leukocyte Disorders::Leukopenia::Agranulocytosis::Neutropenia
KW  - Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Signs and Symptoms, Digestive::Diarrhea
TI  - Influence of BRAF and PIK3CA mutations on the efficacy of FOLFIRI plus bevacizumab or cetuximab as first-line therapy in patients with RAS wild-type metastatic colorectal carcinoma and <3 baseline circulating tumour cells: the randomised phase II VISNÚ-2 study
TY  - research article
ER  -