RT Journal Article
T1 Role of prothrombin complex concentrate in the severe trauma patient.
A1 Egea-Guerrero, Juan Jose
A1 Quintana-Diaz, Manuel
K1 bleeding management protocol
K1 coagulation
K1 massive bleeding
K1 prothrombin
K1 trauma-induced coagulopathy
AB Traumatic hemorrhagic shock causes an estimated annual loss of more than 75 million years of life globally, and mostly affects young people (1). It is a time-dependent process, in which prehospital and emergency interventions must be sufficient to prevent the lethal triad of hypothermia, acidosis, and coagulopathy (2), and to avoid trauma-induced coagulopathy (TIC). Both are key determinants of trauma-associated mortality, so early control is essential to improve prognosis and reduce this outcome (3). During hemorrhagic shock, special attention needs to be paid to hyperfibrinolysis and deficiency of coagulation factors. The latter may be deficient for various reasons, such as loss due to hemorrhage, dilution due to vigorous fluid resuscitation, or the activation of pathophysiological mechanisms in TIC that mediate dysfunctionTraumatic hemorrhagic shock causes an estimated annual loss of more than 75 million years of life globally, and mostly affects young people (1). It is a time-dependent process, in which prehospital and emergency interventions must be sufficient to prevent the lethal triad of hypothermia, acidosis, and coagulopathy (2), and to avoid trauma-induced coagulopathy (TIC). Both are key determinants of trauma-associated mortality, so early control is essential to improve prognosis and reduce this outcome (3). During hemorrhagic shock, special attention needs to be paid to hyperfibrinolysis and deficiency of coagulation factors. The latter may be deficient for various reasons, such as loss due to hemorrhage, dilution due to vigorous fluid resuscitation, or the activation of pathophysiological mechanisms in TIC that mediate dysfunction
PB Frontiers Research Foundation
SN 2296-858X
YR 2022
FD 2022-11-02
LK http://hdl.handle.net/10668/20611
UL http://hdl.handle.net/10668/20611
LA en
NO Egea-Guerrero JJ, Quintana-Diaz M. Role of prothrombin complex concentrate in the severe trauma patient. Front Med (Lausanne). 2022 Nov 2;9:988919.
DS RISalud
RD Oct 27, 2025