RT Journal Article
T1 Adipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC study.
A1 Dossus, Laure
A1 Franceschi, Silvia
A1 Biessy, Carine
A1 Navionis, Anne-Sophie
A1 Travis, Ruth C
A1 Weiderpass, Elisabete
A1 Scalbert, Augustin
A1 Romieu, Isabelle
A1 Tjønneland, Anne
A1 Olsen, Anja
A1 Overvad, Kim
A1 Boutron-Ruault, Marie-Christine
A1 Bonnet, Fabrice
A1 Fournier, Agnès
A1 Fortner, Renee T
A1 Kaaks, Rudolf
A1 Aleksandrova, Krasimira
A1 Trichopoulou, Antonia
A1 La Vecchia, Carlo
A1 Peppa, Eleni
A1 Tumino, Rosario
A1 Panico, Salvatore
A1 Palli, Domenico
A1 Agnoli, Claudia
A1 Vineis, Paolo
A1 Bueno-de-Mesquita, H B As
A1 Peeters, Petra H
A1 Skeie, Guri
A1 Zamora-Ros, Raul
A1 Chirlaque, María-Dolores
A1 Ardanaz, Eva
A1 Sanchez-Perez, Maria-Jose
A1 Ramón Quirós, Jose
A1 Dorronsoro, Miren
A1 Sandström, Maria
A1 Nilsson, Lena Maria
A1 Schmidt, Julie A
A1 Khaw, Kay-Tee
A1 Tsilidis, Konstantinos K
A1 Aune, Dagfinn
A1 Riboli, Elio
A1 Rinaldi, Sabina
K1 adipokine
K1 cytokine
K1 inflammation
K1 prospective cohort
K1 thyroid cancer
AB Other than the influence of ionizing radiation and benign thyroid disease, little is known about the risk factors for differentiated thyroid cancer (TC) which is an increasing common cancer worldwide. Consistent evidence shows that body mass is positively associated with TC risk. As excess weight is a state of chronic inflammation, we investigated the relationship between concentrations of leptin, adiponectin, C-reactive protein, interleukin (IL)-6, IL-10 and tumor necrosis factor (TNF)-α and the risk of TC. A case-control study was nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study and included 475 first primary incident TC cases (399 women and 76 men) and 1,016 matched cancer-free cohort participants. Biomarkers were measured in serum samples using validated and highly sensitive commercially available immunoassays. Odds ratios (ORs) of TC by levels of each biomarker were estimated using conditional logistic regression models, adjusting for BMI and alcohol consumption. Adiponectin was inversely associated with TC risk among women (ORT3vs.T1  = 0.69, 95% CI: 0.49-0.98, Ptrend  = 0.04) but not among men (ORT3vs.T1  = 1.36, 95% CI: 0.67-2.76, Ptrend  = 0.37). Increasing levels of IL-10 were positively associated with TC risk in both genders and significantly so in women (ORT3vs.T1  = 1.59, 95% CI: 1.13-2.25, Ptrend  = 0.01) but not in men (ORT3vs.T1  = 1.78, 95% CI: 0.80-3.98, Ptrend  = 0.17). Leptin, CRP, IL-6 and TNF-α were not associated with TC risk in either gender. These results indicate a positive association of TC risk with IL-10 and a negative association with adiponectin that is probably restricted to women. Inflammation may play a role in TC in combination with or independently of excess weight.
YR 2017
FD 2017-12-20
LK http://hdl.handle.net/10668/11838
UL http://hdl.handle.net/10668/11838
LA en
DS RISalud
RD Apr 5, 2025