RT Journal Article
T1 Oxidative stress parameters and antioxidants in patients with bipolar disorder: Results from a meta-analysis comparing patients, including stratification by polarity and euthymic status, with healthy controls.
A1 Jiménez-Fernández, Sara
A1 Gurpegui, Manuel
A1 Garrote-Rojas, Daniel
A1 Gutiérrez-Rojas, Luis
A1 Carretero, María D
A1 Correll, Christoph U
K1 antioxidants
K1 bipolar disorder
K1 meta-analysis
K1 oxidative stress
K1 polarity
AB To investigate oxidative stress markers and antioxidants in bipolar disorder (BD). Electronic MEDLINE/PubMed/Cochrane-Library/Scopus/TripDatabase search until 06/30/2019 for studies comparing antioxidant or oxidative stress markers between BD and healthy controls (HCs). Standardized mean differences (SMD) and 95% confidence intervals (CIs) were calculated for ≥3 studies. Forty-four studies (n = 3,767: BD = 1,979; HCs = 1,788) reported on oxidative stress markers malondialdehyde (MDA), thiobarbituric acid reactive substances (TBARS), and total nitrites; antioxidants glutathione (GSH), uric acid, and zinc; or antioxidantenhancing enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), and GSH-transferase (GST). Compared with HCs, BD was associated with higher GST (P = .01), CAT (P = .02), nitrites (P  Beyond a single biomarker of oxidative stress, the combination of several parameters appears to be more informative for BD in general and taking into account illness polarity. BD is associated with an imbalance in oxidative stress with some phase-specificity for uric acid and TBARS and possible treatment benefits for SOD and GPX. Future studies should take into account confounding factors that can modify oxidative stress status and simultaneously measure oxidative stress markers and antioxidants including different blood sources.
YR 2020
FD 2020-09-10
LK http://hdl.handle.net/10668/16087
UL http://hdl.handle.net/10668/16087
LA en
DS RISalud
RD Apr 19, 2025