RT Journal Article
T1 Multiple Multicomponent Reactions: Unexplored Substrates, Selective Processes, and Versatile Chemotypes in Biomedicine.
A1 Ghashghaei, Ouldouz
A1 Caputo, Samantha
A1 Sintes, Miquel
A1 Revés, Marc
A1 Kielland, Nicola
A1 Estarellas, Carolina
A1 Luque, F Javier
A1 Aviñó, Anna
A1 Eritja, Ramón
A1 Serna-Gallego, Ana
A1 Marrugal-Lorenzo, José Antonio
A1 Pachón, Jerónimo
A1 Sánchez-Céspedes, Javier
A1 Treadwell, Ryan
A1 de Moliner, Fabio
A1 Vendrell, Marc
A1 Lavilla, Rodolfo
K1 azines
K1 biological activity
K1 isocyanides
K1 multicomponent reactions
K1 novel scaffolds
AB Multiple multicomponent reactions rapidly assemble complex structures. Despite being very productive, the lack of selectivity and the reduced number of viable transformations restrict their general application in synthesis. Hereby, we describe a rationale for a selective version of these processes based in the preferential generation of intermediates which are less reactive than the initial substrates. In this way, applying the Groebke-Blackburn-Bienaymé reaction on a range of α-polyamino-polyazines, we prepared a family compact heterocyclic scaffolds with relevant applications in medicinal and biological chemistry (live cell imaging probes, selective binders for DNA quadruplexes, and antiviral agents against human adenoviruses). The approach has general character and yields complex molecular targets in a selective, tunable and direct manner.
YR 2018
FD 2018-08-28
LK http://hdl.handle.net/10668/12680
UL http://hdl.handle.net/10668/12680
LA en
DS RISalud
RD Apr 18, 2025