%0 Journal Article
%A Gálvez, Rafael
%A Ribera, Victoria
%A González-Escalada, José Ramón
%A Souto, Alicia
%A Cánovas, María Luz
%A Castro, Andrés
%A Herrero, Begoña
%A Maqueda, María de los Ángeles
%A Castilforte, Matilde
%A Marco-Martínez, José Javier
%A Pérez, Concepción
%A Vicente-Fatela, Lorenza
%A Nieto, Consuelo
%A Orduña, Maria José
%A Padrol, Anna
%A Reig, Enrique
%A Carballido, Joaquín
%A Cózar, José Manuel
%T Analgesic efficacy of zoledronic acid and its effect on functional status of  prostate cancer patients with metastasis
%D 2008
%@ 1177-889X (Online)
%U http://hdl.handle.net/10668/652
%X Objectives: A multi-centered observational study evaluated the efficacy of zoledronic acid for improving pain and mobility, and preventing skeletal-related events (SRE) (fracture, spinal compression, pain-relieving radiotherapy), in patients with prostate cancer and bone metastasis.Materials and Methods: Males (n = 218) with prostate cancer and bone metastasis undergoing oncologic therapy received zoledronic acid (4 mg iv/month) for 6 months. Parameters evaluatedwere: 1) pain and movement after 2 consecutive doses; 2) quality of life; 3) SRE incidence and time-to-appearance. Medication tolerance and treatment satisfaction were assessed usinga questionnaire.Results: A total of 170 that matched all the inclusion criteria (78%) out of 218 were evaluable for efficacy. There was a measurable statistically significant reduction in pain at rest and on movement as well as an improvement in the quality of life compared with baseline. Best results were obtained with early treatment. Overall incidence of bone events was 11.2%. Ofthe 212 patients (97.2%) evaluable for safety, 16% suffered adverse events and 66% expressed satisfaction with the treatmentDiscussion: Zoledronic acid is effective for reducing pain, improving mobility, and increasing the quality of life in patients with prostate cancer with bone metastasis. Its easy administration and good tolerability make zoledronic acid one of the principal therapeutic tools in the managementof patients with pain associated with bone metastasis from prostate cancer.
%K Neoplasias de la Próstata
%K Metástasis de la Neoplasia
%K Dolor
%K Difosfonatos
%K Estudios Multicéntricos como Asunto
%K Masculino
%K Bone metastasis
%K Pain
%K Prostate cancer
%K Zoledronic acid
%~