RT Journal Article
T1 Metabolite and lipoprotein profiles reveal sex-related oxidative stress imbalance in de novo drug-naive Parkinson's disease patients
A1 Meoni, Gaia
A1 Tenori, Leonardo
A1 Schade, Sebastian
A1 Licari, Cristina
A1 Pirazzini, Chiara
A1 Bacalini, Maria Giulia
A1 Garagnani, Paolo
A1 Turano, Paola
A1 Trenkwalder, Claudia
A1 Franceschi, Claudio
A1 Mollenhauer, Brit
A1 Luchinat, Claudio
A1 PROPAG-AGEING Consortium, 
K1 Cholesterol levels
K1 Serum-cholesterol
K1 Homocysteine
K1 Biomarkers
K1 Phenotypes
K1 Levodopa
K1 Plasma
K1 Risk
K1 Nmr
AB Parkinson's disease (PD) is the neurological disorder showing the greatest rise in prevalence from 1990 to 2016. Despite clinical definition criteria and a tremendous effort to develop objective biomarkers, precise diagnosis of PD is still unavailable at early stage. In recent years, an increasing number of studies have used omic methods to unveil the molecular basis of PD, providing a detailed characterization of potentially pathological alterations in various biological specimens. Metabolomics could provide useful insights to deepen our knowledge of PD aetiopathogenesis, to identify signatures that distinguish groups of patients and uncover responsive biomarkers of PD that may be significant in early detection and in tracking the disease progression and drug treatment efficacy. The present work is the first large metabolomic study based on nuclear magnetic resonance (NMR) with an independent validation cohort aiming at the serum characterization of de novo drug-naive PD patients. Here, NMR is applied to sera from large training and independent validation cohorts of German subjects. Multivariate and univariate approaches are used to infer metabolic differences that characterize the metabolite and the lipoprotein profiles of newly diagnosed de novo drug-naive PD patients also in relation to the biological sex of the subjects in the study, evidencing a more pronounced fingerprint of the pathology in male patients. The presence of a validation cohort allowed us to confirm altered levels of acetone and cholesterol in male PD patients. By comparing the metabolites and lipoproteins levels among de novo drug-naive PD patients, age- and sex-matched healthy controls, and a group of advanced PD patients, we detected several descriptors of stronger oxidative stress.
PB Nature portfolio
YR 2022
FD 2022-02-08
LK http://hdl.handle.net/10668/19556
UL http://hdl.handle.net/10668/19556
LA en
DS RISalud
RD Apr 17, 2025