RT Journal Article
T1 Antiretroviral therapy as a factor protective against anal dysplasia in HIV-infected males who have sex with males.
A1 Hidalgo-Tenorio, Carmen
A1 Rivero-Rodriguez, Mar
A1 Gil-Anguita, Concepción
A1 Lopez De Hierro, Mercedes
A1 Palma, Pablo
A1 Ramírez-Taboada, Jessica
A1 Esquivias, Javier
A1 López-Ruz, Miguel Angel
A1 Javier-Martínez, Rosario
A1 Pasquau-Liaño, Juan
K1 Seropositividad para VIH
K1 Masculino
K1 Infecciones por Papillomavirus
K1 Canal Anal
K1 Homosexualidad Masculina
K1 Estudios Transversales
K1 Terapia Antirretroviral Altamente Activa
K1 Neoplasias del Ano
AB OBJECTIVESChronic infection with oncogenic HPV genotype is associated with the development of anal dysplasia. Antiretroviral therapy (ART) has been shown to decrease the incidence of cervical carcinoma in women with HIV. We sought to: 1) describe the prevalence and grade of anal dysplasia and HPV infection in our study subjects; 2) analyze the grade of correlation between anal cytology, PCR of high-risk HPV, and histology; 3) identify the factors associated with the appearance of ≥ AIN2 lesions.DESIGNCross-sectional, prospective study.METHODSA cohort of HIV-positive males (n = 140, mean age  = 37 years) who have sex with males (MSM) had epidemiological, clinical and analytical data collected. Anal mucosa samples were taken for cytology, HPV PCR genotyping, and anoscopy for histological analysis.RESULTSWithin the cohort, 77.1% were being treated with ART, 8.5% anoscopy findings were AIN2, and 11.4% carcinoma in situ; 74.2% had high-risk (HR), 59.7% low-risk (LR) HPV genotypes and 46.8% had both. The combination of cytology with PCR identifying HR-HPV better predicts the histology findings than either of these factors alone. Logistic regression highlighted ART as a protective factor against ≥ AIN2 lesions (OR: 0.214; 95%CI: 0.054-0.84). Anal/genital condylomas (OR: 4.26; 95%CI: 1.27-14.3), and HPV68 genotype (OR: 10.6; 95%CI: 1.23-91.47) were identified as risk factors.CONCLUSIONSIn our cohort, ART has a protective effect against dysplastic anal lesions. Anal/genital warts and HPV68 genotype are predictors of ≥ AIN2 lesions. Introducing PCR HPV genotype evaluation improves screening success over that of cytology alone.
PB Public Library of Science
YR 2014
FD 2014-03-27
LK http://hdl.handle.net/10668/1635
UL http://hdl.handle.net/10668/1635
LA en
NO Hidalgo-Tenorio C, Rivero-Rodriguez M, Gil-Anguita C, Lopez De Hierro M, Palma P, Ramírez-Taboada J, et al. Antiretroviral therapy as a factor protective against anal dysplasia in HIV-infected males who have sex with males. PLoS ONE. 2014 ; 9(3):e92376
NO Journal Article;
DS RISalud
RD Apr 7, 2025